Literature summary for 7.2.2.12 extracted from

Mills, R.F.; Francini, A.; Ferreira da Rocha, P.S.; Baccarini, P.J.; Aylett, M.; Krijger, G.C.; Williams, L.E.
The plant P1B-type ATPase AtHMA4 transports Zn and Cd and plays a role in detoxification of transition metals supplied at elevated levels (2005), FEBS Lett., 579, 783-791.

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Protein Variants

Protein Variants	Comment	Organism
C357G	mutant enzyme does not confer Cd and Zn resistance to yeast	Arabidopsis thaliana
additional information	AtHMA4 and a truncated form lacking the last 457 amino acids both confer Cd and Zn resistance to yeast	Arabidopsis thaliana

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ATP + H2O + Cd2+/in	Arabidopsis thaliana	AtHMA4 functions as an efflux pump conferring both Cd and Zn resistance	ADP + phosphate + Cd2+/out	-	?
ATP + H2O + Zn2+/in	Arabidopsis thaliana	AtHMA4 functions as an efflux pump conferring both Cd and Zn resistance	ADP + phosphate + Zn2+/out	-	?

Organism

Organism	UniProt	Comment	Textmining
Arabidopsis thaliana	-	ecotype Columbia	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
ATP + H2O + Cd2+/in	AtHMA4 functions as an efflux pump conferring both Cd and Zn resistance	Arabidopsis thaliana	ADP + phosphate + Cd2+/out	-	?
ATP + H2O + Zn2+/in	AtHMA4 functions as an efflux pump conferring both Cd and Zn resistance	Arabidopsis thaliana	ADP + phosphate + Zn2+/out	-	?

Synonyms

Synonyms	Comment	Organism
AtHMA4	-	Arabidopsis thaliana

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Release 2023.1 (January 2023)