Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 7.2.2.12 extracted from

  • Legatzki, A.; Grass, G.; Anton, A.; Rensing, C.; Nies, D.H.
    Interplay of the Czc system and two P-type ATPases in conferring metal resistance to Ralstonia metallidurans (2003), J. Bacteriol., 185, 4354-4361.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.2.12

Cloned(Commentary)

Cloned (Comment) Organism
The cadA and zntA genes are located on the bacterial chromosome. Expression of zntA in Escherichia coli predominantly mediated resistance to zinc, and expression of cadA predominantly mediated resistance to cadmium. Cupriavidus metallidurans

Protein Variants

Protein Variants Comment Organism
additional information in the plasmid-free strain AE104, single gene deletions of cadA or zntA have only a moderate effect on cadmium and zinc resistance, but zinc resistance decreases 6fold and cadmium resistance decreases 350fold in double deletion strains. Cupriavidus metallidurans

Organism

Organism UniProt Comment Textmining
Cupriavidus metallidurans
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + Zn2+[side 1] = ADP + phosphate + Zn2+[side 2] cadmium and zinc are removed from cells by the CzcCBA efflux pump and by two soft-metal-transporting P-type ATPases, CadA and ZntA. Cupriavidus metallidurans
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + Cd2+/in
-
 Cupriavidus metallidurans ADP + phosphate + Cd2+/out
-
 ?
ATP + H2O + Zn2+/in
-
 Cupriavidus metallidurans ADP + phosphate + Zn2+/out
-
 ?