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Literature summary for 7.2.1.1 extracted from

  • Lin, P.C.; Turk, K.; Hase, C.C.; Fritz, G.; Steuber, J.
    Quinone reduction by the Na+-translocating NADH dehydrogenase promotes extracellular superoxide production in Vibrio cholerae (2007), J. Bacteriol., 189, 3902-3908.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
2-n-heptyl-4-hydroxyquinoline-N-oxide
-
 Vibrio cholerae serotype O1
Ag+ in the presence of Ag+, rates of NADH oxidation by membranes from the parent Vibrio cholera strain decrease to 14% (0.001 mM Ag+) of the activity observed in the absence of the inhibitor Vibrio cholerae serotype O1

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Vibrio cholerae serotype O1 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Na+ environmental Na+ can stimulate ubisemiquinone formation by the Na+-NQR and hereby enhances the production of reactive oxygen species formed during the autoxidation of reduced quinines, increasing the Na+ concentration from below 0.1 mM to 25 mM results in a 3fold stimulation of activity of the purified enzyme Vibrio cholerae serotype O1

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
NADH + H+ + ubiquinone + Na+/in Vibrio cholerae serotype O1
-
 NAD+ + ubiquinol + Na+/out
-
 ?
NADH + H+ + ubiquinone + Na+/in Vibrio cholerae serotype O1 ATCC 39541
-
 NAD+ + ubiquinol + Na+/out
-
 ?

Organism

Organism UniProt Comment Textmining
Vibrio cholerae serotype O1 A5F5X1 and A5F5X0 and A5F5Y7 and A5F5Y6 and A5F5Y3 and A5F5Y4 A5F5X1: subunit NqrA, A5F5X0: subunit NqrB, A5F5Y7: subunit NqrC, A5F5Y6: subunit NqrD; A5F5Y3: subunit NqrE, A5F5Y4: subunit NqrF. The enzyme consists of six subunits encoded by the NQR operon.
-
Vibrio cholerae serotype O1 ATCC 39541 A5F5X1 and A5F5X0 and A5F5Y7 and A5F5Y6 and A5F5Y3 and A5F5Y4 A5F5X1: subunit NqrA, A5F5X0: subunit NqrB, A5F5Y7: subunit NqrC, A5F5Y6: subunit NqrD; A5F5Y3: subunit NqrE, A5F5Y4: subunit NqrF. The enzyme consists of six subunits encoded by the NQR operon.
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + H+ + ubiquinone + Na+/in
-
 Vibrio cholerae serotype O1 NAD+ + ubiquinol + Na+/out
-
 ?
NADH + H+ + ubiquinone + Na+/in
-
 Vibrio cholerae serotype O1 ATCC 39541 NAD+ + ubiquinol + Na+/out
-
 ?

Synonyms

Synonyms Comment Organism
Na+-NQR
-
 Vibrio cholerae serotype O1
Na+-translocating NADH:quinone oxidoreductase
-
 Vibrio cholerae serotype O1

Cofactor

Cofactor Comment Organism Structure
FAD
-
 Vibrio cholerae serotype O1
FMN
-
 Vibrio cholerae serotype O1
NADH
-
 Vibrio cholerae serotype O1
riboflavin
-
 Vibrio cholerae serotype O1
ubiquinone-8
-
 Vibrio cholerae serotype O1
[2Fe-2S]-center the NqrF subunit of the Na+-NQR complex harbors a [2Fe-2S] cluster which accepts electrons from the FAD cofactor Vibrio cholerae serotype O1

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0001
-
 pH and temperature not specified in the publication Vibrio cholerae serotype O1 Ag+