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Literature summary for 7.2.1.1 extracted from

  • Vgenopoulou, I.; Gemperli, A.C.; Steuber, J.
    Specific modification of a Na+ binding site in NADH:quinone oxidoreductase from Klebsiella pneumoniae with dicyclohexylcarbodiimide (2006), J. Bacteriol., 188, 3264-3272.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.2.1.1

Inhibitors

Inhibitors Comment Organism Structure
annonin VI IC50: 0.05 mM Klebsiella pneumoniae
additional information not inhibited by 0.04 mM Ag+ Klebsiella pneumoniae

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Klebsiella pneumoniae 16020
-

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Fractogel DEAE-650(S) column chromatography and Source 15Q Superformance column chromatography Klebsiella pneumoniae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.22
-
 in solubilized membranes Klebsiella pneumoniae
0.77
-
 after purification Klebsiella pneumoniae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + N',N'-dicyclohexylcarbodiimide
-
 Klebsiella pneumoniae NAD+ + ?
-
 ?
NADH + ubiquinone-1
-
 Klebsiella pneumoniae NAD+ + ubiquinol-1
-
 ?

Subunits

Subunits Comment Organism
multimer
-
 Klebsiella pneumoniae

Synonyms

Synonyms Comment Organism
Na+-translocating complex 1
-
 Klebsiella pneumoniae
Na+-translocating NADH:quinone oxidoreductase
-
 Klebsiella pneumoniae
NDH-1
-
 Klebsiella pneumoniae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Klebsiella pneumoniae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.05
-
 IC50: 0.05 mM Klebsiella pneumoniae annonin VI