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Literature summary for 7.1.2.2 extracted from

  • Subrtova, K.; Panicucci, B.; Zikova, A.
    ATPaseTb2, a unique membrane-bound FoF1-ATPase component, is essential in bloodstream and dyskinetoplastic trypanosomes (2015), PLoS Pathog., 11, e1004660 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.2.2

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
 Trypanosoma brucei 31966
-
mitochondrion
-
 Trypanosoma brucei 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + 4 H+[side 1] Trypanosoma brucei
-
 ADP + phosphate + 4 H+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + 4 H+[side 1]
-
 Trypanosoma brucei ADP + phosphate + 4 H+[side 2]
-
 ?

Subunits

Subunits Comment Organism
? x * 40000, subunit ATPaseTb2, SDS-PAGE Trypanosoma brucei

Synonyms

Synonyms Comment Organism
ATPaseTb2 subunit Trypanosoma brucei
FoF1-ATPase
-
 Trypanosoma brucei

General Information

General Information Comment Organism
malfunction silencing of subunit ATPase Tb2 inhibits cell growth by decreasing the mitochondrial membrane potential in bloodstream form of Trypanosoma brucei. Depletion of subunit ATPase Tb2 does not significantly alter ATP hydrolysis capabilities but affects cell growth, the mitochondrial membrane potential and FoF1-ATPase integrity in dyskinetoplastic Trypanosoma brucei evansi Trypanosoma brucei
metabolism the enzyme energizes the inner mitochondrial membrane by coupling ATP hydrolysis with the exchange of ADP3- for ATP4- by the ATP/ADP carrier Trypanosoma brucei
physiological function the membrane-bound ATPaseTb2 subunit is essential for maintaining normal growth and the mitochondrial membrane potential of dyskinetoplastic cells Trypanosoma brucei