Literature summary for 7.1.2.2 extracted from

Yasuno, T.; Muneyuki, E.; Yoshida, M.; Kato-Yamada, Y.
Modulation of nucleotide binding to the catalytic sites of thermophilic F1-ATPase by the epsilon subunit: implication for the role of the epsilon subunit in ATP synthesis (2009), Biochem. Biophys. Res. Commun., 390, 230-234.

Search for more literature for 7.1.2.2

Protein Variants

Protein Variants	Comment	Organism
alphaW463F/betaY341W	site-directed mutagenesis,	Bacillus sp. PS3

Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	strong inhibitory effect of the TF1 epsilon subunit on nucleotide binding	Bacillus sp. PS3

Organism

Organism	UniProt	Comment	Textmining
Bacillus sp. PS3	-	-	-

Subunits

Subunits	Comment	Organism
More	FoF1-ATPase/synthase consists of two rotary molecular motors: a water-soluble, ATP-driven F1 motor and a membrane embedded, H+-driven Fo motor, F1-ATPase is formed by 5 subunits types: alpha3beta3gammadeltaepsilon. F1-ATPase hydrolysis of one ATP drives discrete 120° rotation of the gammaepsilon subunits relative to the other subunits, structure analysis, overview. Strong inhibitory effect of the TF1 epsilon subunit on nucleotide binding, the presence of the extended epsilon subunit will change the rotational potential profile of gamma and epsilon subunits by changing the free energy difference between the nucleotide binding to high and low affinity binding sites. This may directly relate to the role of the epsilon subunit in efficient ATP synthesis under certain conditions	Bacillus sp. PS3

Synonyms

Synonyms	Comment	Organism
F1-ATPase	-	Bacillus sp. PS3
FoF1	-	Bacillus sp. PS3
FoF1-ATPase/synthase	-	Bacillus sp. PS3
TF1	-	Bacillus sp. PS3

General Information

General Information	Comment	Organism
physiological function	FoF1-ATPase/synthase consists of two rotary molecular motors: a water-soluble, ATP-driven F1 motor and a membrane embedded, H+-driven Fo motor. These molecular motors are connected together to couple ATP synthesis/hydrolysis and ion flow.The F1-ATPase hydrolyzes ATP into ADP and inorganic phosphate, and the hydrolysis of one ATP drives discrete 120° rotation of the gammaepsilon subunits relative to the other subunits	Bacillus sp. PS3

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)