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Literature summary for 7.1.2.2 extracted from

  • Wang, H.Q.; Xu, Y.X.; Zhao, X.Y.; Zhao, H.; Yan, J.; Sun, X.B.; Guo, J.C.; Zhu, C.Q.
    Overexpression of F0F1-ATP synthase alpha suppresses mutant huntingtin aggregation and toxicity in vitro (2009), Biochem. Biophys. Res. Commun., 390, 1294-1298.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
transient overexpression of FOF1-ATP synthase alpha in human neuroblastoma SH-SY5Y cells Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrial membrane
-
Mus musculus 31966
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in Mus musculus
-
ADP + phosphate + H+/out
-
r

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in
-
Mus musculus ADP + phosphate + H+/out
-
r

Subunits

Subunits Comment Organism
multimer FOF1-ATP synthase is a multi-subunit protein Mus musculus

Synonyms

Synonyms Comment Organism
ATP synthase
-
Mus musculus
F0F1-ATP synthase
-
Mus musculus
F0F1-ATP synthase alpha
-
Mus musculus
F0F1-ATPase
-
Mus musculus
More the FOF1-ATP synthase alpha belongs to the family of stress proteins HSP60 Mus musculus

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Mus musculus

General Information

General Information Comment Organism
additional information FOF1-ATP synthase plays a role in neurodegenerative diseases, including Alzheimer's disease and Parkinson's disease Mus musculus
physiological function FOF1-ATP synthase synthesizes cellular ATP from ADP and inorganic phosphate. The FOF1-ATP synthase is localized in the mitochondria of eukaryotic cells, where it utilizes the electrochemical gradient, established across the inner mitochondrial membrane by oxidative phosphorylation, for the synthesis of ATP from ADP and inorganic phosphate. Recombinant ATP synthase alpha suppresses huntingtin aggregation when transiently overexpressed in SH-SY5Y cells, overview Mus musculus