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Literature summary for 7.1.2.2 extracted from

  • Champagne, E.; Martinez, L.O.; Collet, X.; Barbaras, R.
    Ecto-F1Fo ATP synthase/F1 ATPase: metabolic and immunologic functions (2006), Curr. Opin. Lipidol., 17, 279-284.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
peptide IF1 a natural inhibitor of the F1-ATPase, which binds at acidic pH, at cell surfaces Bos taurus
peptide IF1 a natural inhibitor of the F1-ATPase, which binds at acidic pH, at cell surfaces Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-
cell surface
-
Bos taurus 9986
-
lipid raft detergent-resistant membrane microdomains enriched in cholesterol and sphingolipid, association with F1-ATPase, overview Homo sapiens
-
-
lipid raft detergent-resistant membrane microdomains enriched in cholesterol and sphingolipid, association with F1-ATPase, overview Bos taurus
-
-
mitochondrial inner membrane
-
Homo sapiens 5743
-
mitochondrial inner membrane
-
Bos taurus 5743
-
plasma membrane
-
Homo sapiens 5886
-
plasma membrane
-
Bos taurus 5886
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in Bos taurus the F1 domain of the F1Fo-ATP synthase complex catalyzes hydrolysis of ATP to ADP, when isolated from the Fo domain or in conditions where the proton gradient is absent or inverted, e.g. hypoxia, promoting a spontaneous reverse rotation of the gamma-subunit which may drive a reverse proton flux ADP + phosphate + H+/out
-
?
ATP + H2O + H+/in Homo sapiens the F1 domain of the F1Fo-ATP synthase complex catalyzes hydrolysis of ATP to ADP, when isolated from the Fo domain or in conditions where the proton gradient isabsent or inverted, e.g. hypoxia, promoting a spontaneous reverse rotation of the gamma-subunit which may drive a reverse proton flux ADP + phosphate + H+/out
-
?
additional information Homo sapiens the F1Fo-ATP synthase acts as cell surface receptor for unrelated ligands, it binds angiostatin on endothelial cell surface, regulates ATP surface levels, and modulates endothelial cell proliferation and differentiation, in addition the enzyme complexes enterostatin on brain cells, or apolipoprotein A-I on hepatocytes mediating HDL internalization and playing a regulatory role in lipoprotein metabolism, mechanism, physiological functions, F1-ATPase acts as a natural target for innate cytotoxicity by killer cell and lymphokine-activated killer cells toards certain tumor cells, overview ?
-
?
additional information Bos taurus the F1Fo-ATP synthase acts as cell surface receptor for unrelated ligands, it binds angiostatin on endothelial cell surface, regulates ATP surface levels, and modulates endothelial cell proliferation and differentiation, in addition the enzyme complexes enterostatin on brain cells, or apolipoprotein A-I on hepatocytes mediating HDL internalization and playing a regulatory role in lipoprotein metabolism, mechanism, physiological functions, F1-ATPase acts as a natural target for innate cytotoxicity by killer cell and lymphokine-activated killer cells toards certain tumor cells, the bovine F1-ATPase specifically activates Vgamma9Vdelta2 T-cell clones, overview ?
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
ATP + H2O + 4 H+[side 1] = ADP + phosphate + 4 H+[side 2] catalytic mechanism of the enzyme complex Homo sapiens
ATP + H2O + 4 H+[side 1] = ADP + phosphate + 4 H+[side 2] catalytic mechanism of the enzyme complex Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
brain
-
Homo sapiens
-
brain
-
Bos taurus
-
carcinoma cell
-
Homo sapiens
-
carcinoma cell
-
Bos taurus
-
HUVEC cell
-
Homo sapiens
-
insulinoma cell
-
Homo sapiens
-
insulinoma cell
-
Bos taurus
-
JURKAT cell
-
Homo sapiens
-
macrophage
-
Homo sapiens
-
macrophage
-
Bos taurus
-
monocyte
-
Homo sapiens
-
monocyte
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in the F1 domain of the F1Fo-ATP synthase complex catalyzes hydrolysis of ATP to ADP, when isolated from the Fo domain or in conditions where the proton gradient is absent or inverted, e.g. hypoxia, promoting a spontaneous reverse rotation of the gamma-subunit which may drive a reverse proton flux Bos taurus ADP + phosphate + H+/out
-
?
ATP + H2O + H+/in the F1 domain of the F1Fo-ATP synthase complex catalyzes hydrolysis of ATP to ADP, when isolated from the Fo domain or in conditions where the proton gradient isabsent or inverted, e.g. hypoxia, promoting a spontaneous reverse rotation of the gamma-subunit which may drive a reverse proton flux Homo sapiens ADP + phosphate + H+/out
-
?
additional information the F1Fo-ATP synthase acts as cell surface receptor for unrelated ligands, it binds angiostatin on endothelial cell surface, regulates ATP surface levels, and modulates endothelial cell proliferation and differentiation, in addition the enzyme complexes enterostatin on brain cells, or apolipoprotein A-I on hepatocytes mediating HDL internalization and playing a regulatory role in lipoprotein metabolism, mechanism, physiological functions, F1-ATPase acts as a natural target for innate cytotoxicity by killer cell and lymphokine-activated killer cells toards certain tumor cells, overview Homo sapiens ?
-
?
additional information the F1Fo-ATP synthase acts as cell surface receptor for unrelated ligands, it binds angiostatin on endothelial cell surface, regulates ATP surface levels, and modulates endothelial cell proliferation and differentiation, in addition the enzyme complexes enterostatin on brain cells, or apolipoprotein A-I on hepatocytes mediating HDL internalization and playing a regulatory role in lipoprotein metabolism, mechanism, physiological functions, F1-ATPase acts as a natural target for innate cytotoxicity by killer cell and lymphokine-activated killer cells toards certain tumor cells, the bovine F1-ATPase specifically activates Vgamma9Vdelta2 T-cell clones, overview Bos taurus ?
-
?

Subunits

Subunits Comment Organism
More the gamma-subunit of the enzyme complex rotates and turns into the F1 domain, when protons cross the membrane, generating conformation changes in the alpha- and beta-chains, which are responsible for catalysis of ATP synthesis from ADP and phosphate, a reserve gamma-subunit rotation reverses the proton flux and promotes ATP hydrolysis, subunit structure of the F1Fo-ATP synthase complex, overview Homo sapiens
More the gamma-subunit of the enzyme complex rotates and turns into the F1 domain, when protons cross the membrane, generating conformation changes in the alpha- and beta-chains, which are responsible for catalysis of ATP synthesis from ADP and phosphate, a reserve gamma-subunit rotation reverses the proton flux and promotes ATP hydrolysis, subunit structure of the F1Fo-ATP synthase complex, overview Bos taurus

Synonyms

Synonyms Comment Organism
Ecto-F1Fo ATP synthase/F1 ATPase
-
Homo sapiens
Ecto-F1Fo ATP synthase/F1 ATPase
-
Bos taurus
F1-ATPase
-
Homo sapiens
F1-ATPase
-
Bos taurus