Inhibitors | Comment | Organism | Structure |
---|---|---|---|
peptide IF1 | a natural inhibitor of the F1-ATPase, which binds at acidic pH, at cell surfaces | Bos taurus | |
peptide IF1 | a natural inhibitor of the F1-ATPase, which binds at acidic pH, at cell surfaces | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
cell surface | - |
Bos taurus | 9986 | - |
lipid raft | detergent-resistant membrane microdomains enriched in cholesterol and sphingolipid, association with F1-ATPase, overview | Homo sapiens | - |
- |
lipid raft | detergent-resistant membrane microdomains enriched in cholesterol and sphingolipid, association with F1-ATPase, overview | Bos taurus | - |
- |
mitochondrial inner membrane | - |
Homo sapiens | 5743 | - |
mitochondrial inner membrane | - |
Bos taurus | 5743 | - |
plasma membrane | - |
Homo sapiens | 5886 | - |
plasma membrane | - |
Bos taurus | 5886 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in | Bos taurus | the F1 domain of the F1Fo-ATP synthase complex catalyzes hydrolysis of ATP to ADP, when isolated from the Fo domain or in conditions where the proton gradient is absent or inverted, e.g. hypoxia, promoting a spontaneous reverse rotation of the gamma-subunit which may drive a reverse proton flux | ADP + phosphate + H+/out | - |
? | |
ATP + H2O + H+/in | Homo sapiens | the F1 domain of the F1Fo-ATP synthase complex catalyzes hydrolysis of ATP to ADP, when isolated from the Fo domain or in conditions where the proton gradient isabsent or inverted, e.g. hypoxia, promoting a spontaneous reverse rotation of the gamma-subunit which may drive a reverse proton flux | ADP + phosphate + H+/out | - |
? | |
additional information | Homo sapiens | the F1Fo-ATP synthase acts as cell surface receptor for unrelated ligands, it binds angiostatin on endothelial cell surface, regulates ATP surface levels, and modulates endothelial cell proliferation and differentiation, in addition the enzyme complexes enterostatin on brain cells, or apolipoprotein A-I on hepatocytes mediating HDL internalization and playing a regulatory role in lipoprotein metabolism, mechanism, physiological functions, F1-ATPase acts as a natural target for innate cytotoxicity by killer cell and lymphokine-activated killer cells toards certain tumor cells, overview | ? | - |
? | |
additional information | Bos taurus | the F1Fo-ATP synthase acts as cell surface receptor for unrelated ligands, it binds angiostatin on endothelial cell surface, regulates ATP surface levels, and modulates endothelial cell proliferation and differentiation, in addition the enzyme complexes enterostatin on brain cells, or apolipoprotein A-I on hepatocytes mediating HDL internalization and playing a regulatory role in lipoprotein metabolism, mechanism, physiological functions, F1-ATPase acts as a natural target for innate cytotoxicity by killer cell and lymphokine-activated killer cells toards certain tumor cells, the bovine F1-ATPase specifically activates Vgamma9Vdelta2 T-cell clones, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Bos taurus | - |
- |
- |
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
ATP + H2O + 4 H+[side 1] = ADP + phosphate + 4 H+[side 2] | catalytic mechanism of the enzyme complex | Homo sapiens | |
ATP + H2O + 4 H+[side 1] = ADP + phosphate + 4 H+[side 2] | catalytic mechanism of the enzyme complex | Bos taurus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
brain | - |
Homo sapiens | - |
brain | - |
Bos taurus | - |
carcinoma cell | - |
Homo sapiens | - |
carcinoma cell | - |
Bos taurus | - |
HUVEC cell | - |
Homo sapiens | - |
insulinoma cell | - |
Homo sapiens | - |
insulinoma cell | - |
Bos taurus | - |
JURKAT cell | - |
Homo sapiens | - |
macrophage | - |
Homo sapiens | - |
macrophage | - |
Bos taurus | - |
monocyte | - |
Homo sapiens | - |
monocyte | - |
Bos taurus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + H2O + H+/in | the F1 domain of the F1Fo-ATP synthase complex catalyzes hydrolysis of ATP to ADP, when isolated from the Fo domain or in conditions where the proton gradient is absent or inverted, e.g. hypoxia, promoting a spontaneous reverse rotation of the gamma-subunit which may drive a reverse proton flux | Bos taurus | ADP + phosphate + H+/out | - |
? | |
ATP + H2O + H+/in | the F1 domain of the F1Fo-ATP synthase complex catalyzes hydrolysis of ATP to ADP, when isolated from the Fo domain or in conditions where the proton gradient isabsent or inverted, e.g. hypoxia, promoting a spontaneous reverse rotation of the gamma-subunit which may drive a reverse proton flux | Homo sapiens | ADP + phosphate + H+/out | - |
? | |
additional information | the F1Fo-ATP synthase acts as cell surface receptor for unrelated ligands, it binds angiostatin on endothelial cell surface, regulates ATP surface levels, and modulates endothelial cell proliferation and differentiation, in addition the enzyme complexes enterostatin on brain cells, or apolipoprotein A-I on hepatocytes mediating HDL internalization and playing a regulatory role in lipoprotein metabolism, mechanism, physiological functions, F1-ATPase acts as a natural target for innate cytotoxicity by killer cell and lymphokine-activated killer cells toards certain tumor cells, overview | Homo sapiens | ? | - |
? | |
additional information | the F1Fo-ATP synthase acts as cell surface receptor for unrelated ligands, it binds angiostatin on endothelial cell surface, regulates ATP surface levels, and modulates endothelial cell proliferation and differentiation, in addition the enzyme complexes enterostatin on brain cells, or apolipoprotein A-I on hepatocytes mediating HDL internalization and playing a regulatory role in lipoprotein metabolism, mechanism, physiological functions, F1-ATPase acts as a natural target for innate cytotoxicity by killer cell and lymphokine-activated killer cells toards certain tumor cells, the bovine F1-ATPase specifically activates Vgamma9Vdelta2 T-cell clones, overview | Bos taurus | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | the gamma-subunit of the enzyme complex rotates and turns into the F1 domain, when protons cross the membrane, generating conformation changes in the alpha- and beta-chains, which are responsible for catalysis of ATP synthesis from ADP and phosphate, a reserve gamma-subunit rotation reverses the proton flux and promotes ATP hydrolysis, subunit structure of the F1Fo-ATP synthase complex, overview | Homo sapiens |
More | the gamma-subunit of the enzyme complex rotates and turns into the F1 domain, when protons cross the membrane, generating conformation changes in the alpha- and beta-chains, which are responsible for catalysis of ATP synthesis from ADP and phosphate, a reserve gamma-subunit rotation reverses the proton flux and promotes ATP hydrolysis, subunit structure of the F1Fo-ATP synthase complex, overview | Bos taurus |
Synonyms | Comment | Organism |
---|---|---|
Ecto-F1Fo ATP synthase/F1 ATPase | - |
Homo sapiens |
Ecto-F1Fo ATP synthase/F1 ATPase | - |
Bos taurus |
F1-ATPase | - |
Homo sapiens |
F1-ATPase | - |
Bos taurus |