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Literature summary for 7.1.2.1 extracted from

  • Muroi, M.; Shiragami, N.; Takatsuki, A.
    Destruxin B, a specific and readily reversible inhibitor of vacuolar-type H+-translocating ATPase (1994), Biochem. Biophys. Res. Commun., 205, 1358-1365 .
    View publication on PubMed
Search for more literature for 7.1.2.1

Cloned(Commentary)

Cloned (Comment) Organism
expressed in BHK-21 cells Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
bafilomycin A1
-
 Saccharomyces cerevisiae
destruxin B specific and reversible inhibition, complete inhibition at concentrations above 0.02 mM Saccharomyces cerevisiae
folimycin
-
 Saccharomyces cerevisiae
N-ethylmaleimide
-
 Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
vacuolar membrane
-
 Saccharomyces cerevisiae 5774
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+[side 1] Saccharomyces cerevisiae
-
 ADP + phosphate + H+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+[side 1]
-
 Saccharomyces cerevisiae ADP + phosphate + H+[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
V-ATPase
-
 Saccharomyces cerevisiae
vacuolar-type H+-translocating ATPase
-
 Saccharomyces cerevisiae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.000004
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae folimycin
0.00002
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae bafilomycin A1
0.0054
-
 pH and temperature not specified in the publication Saccharomyces cerevisiae destruxin B