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Literature summary for 7.1.2.1 extracted from

  • Santos, J.M.; Martinez-Zaguilan, R.; Facanha, A.R.; Hussain, F.; Sennoune, S.R.
    Vacuolar H+-ATPase in the nuclear membranes regulates nucleo-cytosolic proton gradients (2016), Am. J. Physiol. Cell Physiol., 311, C547-C558 .
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
bafilomycin
-
Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
nuclear membrane
-
Homo sapiens 31965
-
plasma membrane
-
Homo sapiens 5886
-
vacuole
-
Homo sapiens 5773
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 3 mM used in assay conditions Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+[side 1] Homo sapiens
-
ADP + phosphate + H+[side 2]
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
LNCaP cell
-
Homo sapiens
-
prostate cancer cell CL-2 cell Homo sapiens
-
prostate epithelium cell line
-
Homo sapiens
-
RWPE-1 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+[side 1]
-
Homo sapiens ADP + phosphate + H+[side 2]
-
?

Synonyms

Synonyms Comment Organism
V-H+-ATPase
-
Homo sapiens
vacuolar H+-ATPase
-
Homo sapiens

General Information

General Information Comment Organism
physiological function vacuolar H+-ATPase is responsible for the creation and maintenance of trans-membrane electrochemical gradients in the nuclear membranes Homo sapiens