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Literature summary for 7.1.2.1 extracted from

  • Diakov, T.T.; Kane, P.M.
    Regulation of vacuolar proton-translocating ATPase activity and assembly by extracellular pH (2010), J. Biol. Chem., 285, 23771-23778.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.2.1

Inhibitors

Inhibitors Comment Organism Structure
concanamycin A
-
 Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.161
-
 ATP enzyme in vesicles from pH 7.0-grown cells, pH and temperature not specified in the publication Saccharomyces cerevisiae
0.184
-
 ATP enzyme in vesicles from pH 5.0-grown cells, pH and temperature not specified in the publication Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
vacuole
-
 Saccharomyces cerevisiae 5773
-

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-
Saccharomyces cerevisiae SF838-5A
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in
-
 Saccharomyces cerevisiae ADP + phosphate + H+/out
-
 ?
ATP + H2O + H+/in
-
 Saccharomyces cerevisiae SF838-5A ADP + phosphate + H+/out
-
 ?

Synonyms

Synonyms Comment Organism
V-ATPase
-
 Saccharomyces cerevisiae
vacuolar proton-translocating ATPase
-
 Saccharomyces cerevisiae

Expression

Organism Comment Expression
Saccharomyces cerevisiae there is 57% higher enzyme activity in vacuoles isolated after cell growth at extracellular pH of 7.0 than after growth at pH 5.0 in minimal medium up

General Information

General Information Comment Organism
physiological function vacuolar proton-translocating ATPase is responsible for organelle acidification Saccharomyces cerevisiae