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Literature summary for 7.1.2.1 extracted from

  • McHenry, P.; Wang, W.L.; Devitt, E.; Kluesner, N.; Davisson, V.J.; McKee, E.; Schweitzer, D.; Helquist, P.; Tenniswood, M.
    Iejimalides A and B inhibit lysosomal vacuolar H+-ATPase (V-ATPase) activity and induce S-phase arrest and apoptosis in MCF-7 cells (2010), J. Cell. Biochem., 109, 634-642.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
iejimalide A a macrolide that is cytostatic or cytotoxic against a wide range of cancer cells at low nanomolar concentrations, inhibits vacuolar H+-ATPase in the context of epithelial tumor cells leading to a lysosome-initiated cell death process, overview Homo sapiens
iejimalide B a macrolide that is cytostatic or cytotoxic against a wide range of cancer cells at low nanomolar concentrations, inhibits vacuolar H+-ATPase in the context of epithelial tumor cells leading to a lysosome-initiated cell death process, overview Homo sapiens
additional information both inhibitors, iejimalides A and B, sequentially neutralize the pH of lysosomes, induce S-phase cell-cycle arrest, and trigger apoptosis in MCF-7 cells, overview Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
lysosome
-
Homo sapiens 5764
-
vacuole vacuolar H+-ATPase Homo sapiens 5773
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ATP + H2O + H+/in Homo sapiens
-
ADP + phosphate + H+/out
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
breast cancer cell
-
Homo sapiens
-
MCF-7 cell
-
Homo sapiens
-
osteoclast vacuolar H+-ATPase Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in
-
Homo sapiens ADP + phosphate + H+/out
-
?

Synonyms

Synonyms Comment Organism
V-ATPase
-
Homo sapiens
vacuolar H+-ATPase
-
Homo sapiens