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Literature summary for 7.1.2.1 extracted from

  • Grigore, D.; Meade, J.C.
    Functional complementation of the yeast P-type H-ATPase, PMA1, by the Pneumocystis carinii P-type H-ATPase, PCA1 (2006), J. Eukaryot. Microbiol., 53, 157-164.
    View publication on PubMed
Search for more literature for 7.1.2.1

Cloned(Commentary)

Cloned (Comment) Organism
expression in Saccharomyces cerevisiae Pneumocystis carinii

Protein Variants

Protein Variants Comment Organism
additional information enzyme contains an inhibitory C-terminal domain, removal of the final 40 amino acids significantly Vmax value and growth of cells at pH 6.5. Enzyme is functional in Saccharomyces cerevisiae Pneumocystis carinii

Inhibitors

Inhibitors Comment Organism Structure
lansoprazole
-
 Pneumocystis carinii
additional information not inhibitory: SCH28080 Pneumocystis carinii
Omeprazole
-
 Pneumocystis carinii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.434
-
 ATP wild-type, pH 6.5 Pneumocystis carinii
0.636
-
 ATP wild-type lacking C-terminal 40 amino acids, pH 6.5 Pneumocystis carinii

Organism

Organism UniProt Comment Textmining
Pneumocystis carinii
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + H2O + H+/in
-
 Pneumocystis carinii ADP + phosphate + H+/out
-
 ?

Synonyms

Synonyms Comment Organism
P-type H+-ATPase
-
 Pneumocystis carinii
PCA1
-
 Pneumocystis carinii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.5
-
-
 Pneumocystis carinii

pH Range

pH Minimum pH Maximum Comment Organism
3.5 7.5
-
 Pneumocystis carinii