Literature summary for 7.1.2.1 extracted from

Chan, G.; Hardej, D.; Santoro, M.; Lau-Cam, C.; Billack, B.
Evaluation of the antimicrobial activity of ebselen: role of the yeast plasma membrane H+-ATPase (2007), J. Biochem. Mol. Toxicol., 21, 252-264.

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Inhibitors

Inhibitors	Comment	Organism	Structure
2-phenyl-1,2-benzisoselenazol-3(2H)-one	i.e. ebselen, inhibition of enzyme results in inhibition of medium acidification. Fungicidal effect is at least in part due to interference with both the proton-translocating function and the ATPase activity of plasma membrane H+-ATPase	Bacillus subtilis
2-phenyl-1,2-benzisoselenazol-3(2H)-one	i.e. ebselen, inhibition of enzyme results in inhibition of medium acidification. Fungicidal effect is at least in part due to interference with both the proton-translocating function and the ATPase activity of plasma membrane H+-ATPase	Micrococcus luteus
2-phenyl-1,2-benzisoselenazol-3(2H)-one	i.e. ebselen, inhibition of enzyme results in inhibition of medium acidification. Fungicidal effect is at least in part due to interference with both the proton-translocating function and the ATPase activity of plasma membrane H+-ATPase	Saccharomyces cerevisiae
2-phenyl-1,2-benzisoselenazol-3(2H)-one	i.e. ebselen, inhibition of enzyme results in inhibition of medium acidification. Fungicidal effect is at least in part due to interference with both the proton-translocating function and the ATPase activity of plasma membrane H+-ATPase	Staphylococcus aureus

Organism

Organism	UniProt	Comment	Textmining
Bacillus subtilis	-	-	-
Micrococcus luteus	-	-	-
Saccharomyces cerevisiae	-	-	-
Staphylococcus aureus	-	-	-

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Release 2023.1 (January 2023)