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Literature summary for 7.1.1.9 extracted from
- Rationally designed molecules for resurgence of cyanide mitigated cytochrome c oxidase activity (2019), Bioorg. Chem., 82, 229-240 .
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| (3Z)-3-[(4-hydroxy-3,5-dimethoxyphenyl)methylidene]-1-[3-[(5-hydroxy-4-oxo-2-phenyl-4H-1-benzopyran-7-yl)oxy]propyl]-1,3-dihydro-2H-indol-2-one | compound developed for clipping cyanide from the enzyme and restoring its normal function. The binding constant with CN- is 230000 per M and its ED50 for restoring the cyanide bound CcOX activity in 10 min is 16 microM. The compound interacts with CN- over the pH range 5-10 | Bos taurus |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Bos taurus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CcOX | - |
Bos taurus |
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Release 2023.1 (January 2023)
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