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Literature summary for 7.1.1.9 extracted from

  • Hiser, C.; Buhrow, L.; Liu, J.; Kuhn, L.; Ferguson-Miller, S.
    A conserved amphipathic ligand binding region influences K-path-dependent activity of cytochrome C oxidase (2013), Biochemistry, 52, 1385-1396 .
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
(4Z,7Z,10Z,13Z,16Z,19Z)-docosa-4,7,10,13,16,19-hexaenoate
-
Cereibacter sphaeroides
arachidonic acid
-
Cereibacter sphaeroides
phytanic acid
-
Cereibacter sphaeroides

Protein Variants

Protein Variants Comment Organism
E10A the mutant shows 50% of wild type activity Cereibacter sphaeroides

Inhibitors

Inhibitors Comment Organism Structure
C12E8
-
Cereibacter sphaeroides
chenodeoxycholate
-
Cereibacter sphaeroides
CHOBIMALT
-
Cereibacter sphaeroides
cholate
-
Cereibacter sphaeroides
dodecyl beta-D-maltopyranoside
-
Cereibacter sphaeroides
lithocholate
-
Cereibacter sphaeroides
lysophophatidylcholine
-
Cereibacter sphaeroides
additional information ursodeoxycholateand glycochenodeoxycholate have no observable effect on enzyme activity Cereibacter sphaeroides
Triton X-100
-
Cereibacter sphaeroides

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Cereibacter sphaeroides 16020
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ferrocytochrome c + O2 + H+ Cereibacter sphaeroides
-
ferricytochrome c + H2O
-
?
ferrocytochrome c + O2 + H+ Cereibacter sphaeroides 37-2
-
ferricytochrome c + H2O
-
?

Organism

Organism UniProt Comment Textmining
Cereibacter sphaeroides P33517
-
-
Cereibacter sphaeroides 37-2 P33517
-
-

Purification (Commentary)

Purification (Comment) Organism
metal affinity column chromatography Cereibacter sphaeroides

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ferrocytochrome c + O2 + H+
-
Cereibacter sphaeroides ferricytochrome c + H2O
-
?
ferrocytochrome c + O2 + H+
-
Cereibacter sphaeroides 37-2 ferricytochrome c + H2O
-
?

Synonyms

Synonyms Comment Organism
CCO
-
Cereibacter sphaeroides
cytochrome c oxidase
-
Cereibacter sphaeroides

Cofactor

Cofactor Comment Organism Structure
heme
-
Cereibacter sphaeroides