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Literature summary for 7.1.1.9 extracted from
- Mitochondrial respiration and membrane potential are regulated by the allosteric ATP-inhibition of cytochrome c oxidase (2010), Biochim. Biophys. Acta, 1797, 1672-1680.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| ADP | - |
Rattus norvegicus |  |
| ADP | - |
Bos taurus | |
| Tween-20 | - |
Bos taurus | |
| Tween-20 | the CcO activity of rat liver and heart mitochondria in the presence of 5 mM ADP increases with increasing Tween-20 concentrations. With rat liver mitochondria almost no CcO activity is found in the absence of Tween-20 in contrast to heart mitochondria, where about 50% of maximal activity is measured. Maximal activity rates are measured between 0.5% and 2% (v/v) Tween-20 | Rattus norvegicus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ATP | the ATP-inhibition of CcO is only effective at very high ATP/ADP ratios (above 50) in the mitochondrial matrix or at low concentrations of ferrocytochrome c | Bos taurus | |
| ATP | the ATP-inhibition of CcO is only effective at very high ATP/ADP ratios (above 50) in the mitochondrial matrix or at low concentrations of ferrocytochrome c | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Rattus norvegicus | 5739 | - |
| mitochondrion | - |
Bos taurus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Rattus norvegicus | - |
| heart | - |
Bos taurus | - |
| kidney | - |
Bos taurus | - |
| liver | - |
Rattus norvegicus | - |
| liver | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ferrocytochrome c + O2 + H+ | - |
Rattus norvegicus | ferricytochrome c + H2O | - |
? | |
| ferrocytochrome c + O2 + H+ | - |
Bos taurus | ferricytochrome c + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CCO | - |
Rattus norvegicus |
| CCO | - |
Bos taurus |
| complex IV | - |
Rattus norvegicus |
| complex IV | - |
Bos taurus |
| cytochrome c oxidase | - |
Rattus norvegicus |
| cytochrome c oxidase | - |
Bos taurus |
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Release 2023.1 (January 2023)
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