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Literature summary for 7.1.1.9 extracted from
- Exogenous cytochrome C restores myocardial cytochrome oxidase activity into the late phase of sepsis (2008), Shock, 29, 612-616.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | a single injection of exogenous cytochrome c 24 h post-cecal ligation and puncture repletes mitochondrial substrate levels for up to 72 h, restores myocardial COX activity, and significantly improves survival | Mus musculus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | is competitively inhibited early in sepsis and progresses, becoming noncompetitive during the late phase. Exogenous cytochrome c can overcome this myocardial CcOX competitive inhibition. Cecal ligation and puncture inhibit CcOX at 48 h in saline-injected mice. However, cytochrome c injection abrogates this inhibition and restores CcOX kinetic activity to sham values at 48 h | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mus musculus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
- |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CcOX | - |
Mus musculus |
| COX | - |
Mus musculus |
| cytochrome oxidase | - |
Mus musculus |
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Release 2023.1 (January 2023)
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