Activating Compound | Comment | Organism | Structure |
---|---|---|---|
3-Amino-1,2,4-triazole | - |
Arabidopsis thaliana | |
salicylic acid | produces a slight and transient increase in transcript levels of COX19 | Arabidopsis thaliana | |
sodium nitroprusside | produces a several fold increase in COX19 expression after 4 h of treatment, but transcript levels return to normal values after higher incubation times | Arabidopsis thaliana |
Application | Comment | Organism |
---|---|---|
additional information | Arabidopsis thaliana COX19 genes encode functional homologues of the yeast metal chaperone. Smaller COX19-1 isoform, but not the larger one, is able to restore growth on non-fermentable carbon sources when expressed in a yeast cox19 null mutant. Induction by biotic and abiotic stress factors may indicate a relevant role of this protein in the biogenesis of cytochrome c oxidase to replace damaged forms of the enzyme. COX19 has additional functions besides its participation in COX assembly as, for example, metal transport, detoxification, or general protection against oxidative stress | Arabidopsis thaliana |
Cloned (Comment) | Organism |
---|---|
cDNAs from both COX19-1 splice variants cloned in the sense and antisense orientations in plasmid pYPGE15, containing a constitutive phosphoglycerate kinase gene promoter and a CYC1 terminator. Expressed in a yeast cox19 null mutant | Arabidopsis thaliana |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | import of COX19 is not inhibited by the ionophore valinomycin indicating that an electrical membrane potential is not required | Arabidopsis thaliana |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
inner membrane | AtCOX19 isoforms are imported into mitochondria in vitro and are attached to the inner membrane facing the intermembrane space | Arabidopsis thaliana | - |
- |
mitochondrion | - |
Arabidopsis thaliana | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Cu2+ | increases COX19 transcript levels | Arabidopsis thaliana | |
Fe2+ | - |
Arabidopsis thaliana | |
Zn2+ | - |
Arabidopsis thaliana |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Arabidopsis thaliana | - |
ecotype Columbia | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
anther | highly stained in AtCOX19-1::GUS plants | Arabidopsis thaliana | - |
leaf | expression in leaves is only observed when cuts are produced, suggesting an induction by wounding | Arabidopsis thaliana | - |
additional information | infection of plants with the pathogenic bacterium Pseudomonas syringae pv. tomato induces COX19 gene expression | Arabidopsis thaliana | - |
root | highly stained in AtCOX19-1::GUS plants. Activity in roots is already evident at very early stages of development (1-2 days after imbibition), but not in embryos at late stages of embryogenesis and is higher in the root meristem, the vascular cylinder and nascent secondary roots | Arabidopsis thaliana | - |
Synonyms | Comment | Organism |
---|---|---|
COX19 | - |
Arabidopsis thaliana |
cytochrome c oxidase | - |
Arabidopsis thaliana |