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Literature summary for 7.1.1.9 extracted from
- Caffeine stimulates cytochrome oxidase expression and activity in the striatum in a sexually dimorphic manner (2008), Mol. Pharmacol., 74, 673-684.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| Caffeine | increases Cox7c mRNA expression in PC-12 cells. This occurrs at the level of transcription and is mediated by a segment of the Cox7c promoter | Rattus norvegicus |  |
| Caffeine | increases Cox7c mRNA expression in the male striatum. Cox7c is up-regulated in the striatum of male but not female mice after receiving a single dose of caffeine. Cox1 and Cox4 are also stimulated by caffeine in a male-specific fashion. A2AR-specific agonist 2-[p-(2-carboxyethyl)phenethylamino]-5'-N-ethylcarboxamidoadenosine counteracts the elevation of Cox expression and activity by caffeine | Mus musculus | |
| SCH58261 | A2AR antagonist, which stimulates Cox expression and activity | Mus musculus | |
| siRNA | knockdown of Cox7c expression in PC-12 cells blunts Cox activity, which is counteracted by caffeine treatment | Rattus norvegicus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | cytochrome oxidase is a metabolic target of caffeine. Stimulation of Cox activity by caffeine via blockade of A2AR signaling may be an important mechanism underlying the therapeutic benefits of caffeine in Parkinsons disease | Rattus norvegicus |
| medicine | cytochrome oxidase is a metabolic target of caffeine. Stimulation of Cox activity by caffeine via blockade of A2AR signaling may be an important mechanism underlying the therapeutic benefits of caffeine in Parkinsons disease | Mus musculus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| inner membrane | - |
Mus musculus | - |
- |
| mitochondrion | - |
Mus musculus | 5739 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 5444 | - |
Cox7c, mass spectrometry | Mus musculus |
| 18000 | - |
Cox4, immunoblot analysis | Mus musculus |
| 35000 | - |
Cox1, immunoblot analysis | Mus musculus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | P17665 | C57B6/S129 mice | - |
| Mus musculus C57B6 / S129 | P17665 | C57B6/S129 mice | - |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partially purified by gel filtration | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | striatum | Mus musculus | - |
| PC-12 cell | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 3,3'-diaminobenzidene-tetrahydrochloride + O2 + H+ | - |
Rattus norvegicus | ? + H2O | - |
? | |
| 3,3'-diaminobenzidene-tetrahydrochloride + O2 + H+ | - |
Mus musculus | ? + H2O | - |
? | |
| 3,3'-diaminobenzidene-tetrahydrochloride + O2 + H+ | - |
Mus musculus C57B6 / S129 | ? + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| COX | - |
Rattus norvegicus |
| COX1 | - |
Mus musculus |
| COX4 | - |
Mus musculus |
| Cox7c | - |
Mus musculus |
| cytochrome oxidase | - |
Rattus norvegicus |
| cytochrome oxidase | - |
Mus musculus |
| cytochrome oxidase VIIc | - |
Mus musculus |
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Release 2023.1 (January 2023)
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