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Literature summary for 7.1.1.9 extracted from

  • Helling, S.; Vogt, S.; Rhiel, A.; Ramzan, R.; Wen, L.; Marcus, K.; Kadenbach, B.
    Phosphorylation and kinetics of mammalian cytochrome c oxidase (2008), Mol. Cell. Proteomics, 7, 1714-1724.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.9

Application

Application Comment Organism
medicine relationship between the allosteric ATP-inhibition and phosphorylation of CcO subunit I, which apparently occurs in living cells, but is lost under stress (e.g. hypoxic stress) Rattus norvegicus
medicine relationship between the allosteric ATP-inhibition and phosphorylation of CcO subunit I, which apparently occurs in living cells, but is lost under stress (e.g. hypoxic stress) Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
additional information incubation of the isolated enzyme with protein kinase A, cAMP, and ATP results in serine and threonine phosphorylation of CcO subunit I, which is correlated with sigmoidal inhibition kinetics in the presence of ATP Bos taurus
additional information rapid isolation of mitochondria from rat heart in the presence of various protein phosphatase inhibitors (in the presence of 25 mM NaF, 5 mM sodium vanadate, 10 nM okadaic acid, 2 mM EGTA, and 0.2% bovine serum albumin) results in CcO kinetics with allosteric ATP-inhibition and phosphorylation of subunit I at serine, threonine, and tyrosine Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-
mitochondrion
-
 Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-
Rattus norvegicus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
by gel filtration Rattus norvegicus
by gel filtration Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Rattus norvegicus
-
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
reduced cytochrome c + O2 + H+
-
 Rattus norvegicus oxidized cytochrome c + H2O
-
 ?
reduced cytochrome c + O2 + H+
-
 Bos taurus oxidized cytochrome c + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CCO
-
 Rattus norvegicus
CCO
-
 Bos taurus
cytochrome c oxidase
-
 Rattus norvegicus
cytochrome c oxidase
-
 Bos taurus