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Literature summary for 7.1.1.9 extracted from

  • Johnson, W.T.; Anderson, C.M.
    Cardiac cytochrome C oxidase activity and contents of subunits 1 and 4 are altered in offspring by low prenatal copper intake by rat dams (2008), J. Nutr., 138, 1269-1273.
    View publication on PubMed
Search for more literature for 7.1.1.9

Application

Application Comment Organism
medicine low prenatal Cu intake by dams is the determinant of CCO activity in cardiac mitochondria of 21-d-old offspring and may lead to the assembly of a less-than-fully active holoenzyme Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
additional information CCO activity, the content of the mitochondrial-encoded CCO subunit 1 (COX1), and the content of the nuclear-encoded subunit COX4 in cardiac mitochondria are reduced in 21-d-old offspring of Cu-deficient dams. COX1 content is normal in 21-d-old cross-fostered offspring of Cu-deficient dams, but CCO activity and COX4 are reduced Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 female Sprague-Dawley rats
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ferrocytochrome c + O2 + H+
-
 Rattus norvegicus ferricytochrome c + H2O
-
 ?

Synonyms

Synonyms Comment Organism
CCO
-
 Rattus norvegicus
CCO subunit 1
-
 Rattus norvegicus
COX1
-
 Rattus norvegicus
COX4
-
 Rattus norvegicus
cytochrome c oxidase
-
 Rattus norvegicus