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Literature summary for 7.1.1.9 extracted from

  • Jekabsone, A.; Neher, J.J.; Borutaite, V.; Brown, G.C.
    Nitric oxide from neuronal nitric oxide synthase sensitises neurons to hypoxia-induced death via competitive inhibition of cytochrome oxidase (2007), J. Neurochem., 103, 346-356.
    View publication on PubMed
Search for more literature for 7.1.1.9

Application

Application Comment Organism
medicine hypoxia synergises with NO from neuronal nitric oxide synthase to induce neuronal death via cytochrome oxidase inhibition causing neuronal depolarisation. Neuronal nitric oxide synthase activity sensitises the cells to hypoxic-inhibition of cytochrome oxidase Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
azide uncompetitive inhibitor, inhibits the oxidase activity both in hypoxia and normoxia Rattus norvegicus
cyanide
-
 Rattus norvegicus
diethylenetriamine-NONOate
-
 Rattus norvegicus
NO inhibits cytochrome oxidase in competition with oxygen. Hypoxia (2% O2) markedly inhibits cytochrome oxidase activity (relative to normoxia), and N-4S-4-amino-5-2-aminoethylaminopentyl-N'-nitroguanidine reverses this inhibition in the presence of hypoxia, but has no effect in normoxia Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
 Wistar rats
-

Source Tissue

Source Tissue Comment Organism Textmining
additional information neuronal-glial culture Rattus norvegicus
-
neuron
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tetramethyl-phenylenediamine + O2 + H+
-
 Rattus norvegicus ? + H2O
-
 ?

Synonyms

Synonyms Comment Organism
cytochrome oxidase
-
 Rattus norvegicus