Literature summary for 7.1.1.9 extracted from

Norman, J.P.; Perry, S.W.; Kasischke, K.A.; Volsky, D.J.; Gelbard, H.A.
HIV-1 trans activator of transcription protein elicits mitochondrial hyperpolarization and respiratory deficit, with dysregulation of complex IV and nicotinamide adenine dinucleotide homeostasis in cortical neurons (2007), J. Immunol., 178, 869-876.

Search for more literature for 7.1.1.9

Application

Application	Comment	Organism
medicine	in HIV-associated dementia, cortical neurons demonstrate decreased respiration upon HIV-1 neurotoxin trans activator of transcription proteint treatment, consistent with inhibition of the enzyme	Rattus norvegicus

Inhibitors

Inhibitors	Comment	Organism	Structure
HIV-1 neurotoxin trans activator of transcription protein	inhibits the electron transport chain in a concentration-dependent manner. A concentration of 5 ng/ml, 50 ng/ml, and 10 microg/ml inhibit activity to 84, 47, and 35% of control, respectively	Rattus norvegicus
potassium cyanide	-	Rattus norvegicus

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Rattus norvegicus	5739	-

Organism

Organism	UniProt	Comment	Textmining
Rattus norvegicus	-	Sprague-Dawley rats	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
embryo	-	Rattus norvegicus	-
neuron	-	Rattus norvegicus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
reduced cytochrome c + O2 + H+	-	Rattus norvegicus	oxidized cytochrome c + H2O	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)