Literature summary for 7.1.1.9 extracted from

Sugio, T.; Fujii, M.; Ninomiya, Y.; Kanao, T.; Negishi, A.; Takeuchi, F.
Reduction of Hg2+ with reduced mammalian cytochrome c by cytochrome c oxidase purified from a mercury-resistant acidithiobacillus ferrooxidans strain, MON-1 (2008), Biosci. Biotechnol. Biochem., 72, 1756-1763.

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Application

Application	Comment	Organism
additional information	cytochrome c oxidase is involved in mercury reduction in Acidithiobacillus ferrooxidans cells. Levels of mercury resistance in Acidithiobacillus ferrooxidans strains correspond well with the levels of mercury resistance of cytochrome c oxidase	Acidithiobacillus ferrooxidans

Inhibitors

Inhibitors	Comment	Organism	Structure
Hg2+	cytochrome c oxidase activities of strains AP19-3 and ATCC 23270 are completely inhibited by 0.001 mM and 0.005 mM. Strain MON-1 is inhibited 33% by 0.005 mM, and 70% by 0.010 mM	Acidithiobacillus ferrooxidans
NaCN	1 mM completely inhibits mercury volatilization activities with reduced cytochrome c and 2,3,5,6-tetramethyl-p-phenylendiamine in strain MON-1	Acidithiobacillus ferrooxidans

Organism

Organism	UniProt	Comment	Textmining
Acidithiobacillus ferrooxidans	-	strains MON-1, AP19-3 and ATCC 23270	-

Purification (Commentary)

Purification (Comment)	Organism
strain MON-1 purified 19.4fold by gel filtration	Acidithiobacillus ferrooxidans

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg]	Specific Activity Maximum [µmol/min/mg]	Comment	Organism
2.7	-	strain MON-1	Acidithiobacillus ferrooxidans
52.5	-	strain MON-1, 19.4fold purified	Acidithiobacillus ferrooxidans

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2,3,5,6-tetramethyl-p-phenylendiamine + O2 + H+	-	Acidithiobacillus ferrooxidans	? + H2O	-	?
reduced horse cytochrome c + O2 + H+	-	Acidithiobacillus ferrooxidans	oxidized horse cytochrome c + H2O	-	?

Synonyms

Synonyms	Comment	Organism
cytochrome c oxidase	-	Acidithiobacillus ferrooxidans

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Release 2023.1 (January 2023)