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Literature summary for 7.1.1.9 extracted from

  • Napoli, E.; Morin, D.; Bernhardt, R.; Buckpitt, A.; Cortopassi, G.
    Hemin rescues adrenodoxin, heme a and cytochrome oxidase activity in frataxin-deficient oligodendroglioma cells (2007), Biochim. Biophys. Acta, 1772, 773-780.
    View publication on PubMed
Search for more literature for 7.1.1.9

Application

Application Comment Organism
medicine cytochrome oxidase deficiency is a result of heme deficiency that may be relevant to the demyelinating phenotype of the neurodegenerative disease Friedreich's ataxia. Heme-based stimulation of iron–sulfur cluster biogenesis is a rational strategy for the neurodegenerative disease Friedreich's ataxia Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information knocked down frataxin in oligodendroglioma cells using siRNA produces significant defects in the activity of cytochrome oxidase. Exogenous hemin produces a significant rescue of cytochrome oxidase activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Homo sapiens 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HOG cell
-
 Homo sapiens
-
oligodendrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
o-dianisidine + H2O2
-
 Homo sapiens ?
-
 ?
reduced horse cytochrome c + O2 + H+
-
 Homo sapiens oxidized horse cytochrome c + H2O
-
 ?

Synonyms

Synonyms Comment Organism
COX
-
 Homo sapiens
cytochrome oxidase
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
heme a acts as the electron transport prosthetic group of the enzyme Homo sapiens