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Literature summary for 7.1.1.9 extracted from
- Peroxidase activity of mitochondrial cytochrome c oxidase (2007), Biochemistry (Moscow), 72, 1056-1064.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | decreasing pH from 8.0 to 6.4 is accompanied by a 5fold increase of cytochrome oxidase activity | Bos taurus |
Application
| Application | Comment | Organism |
|---|---|---|
| drug development | possibility of nonspecific peroxidation of various substances catalyzed by cytochrome oxidase via the peroxidase mechanism, which may contribute to intracellular metabolism of biologically active drugs (under conditions of cardiotoxicity) and other compounds | Bos taurus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| cyanide | - |
Bos taurus |  |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.09 | - |
o-Dianisidine | at 1 mM H2O2 | Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Bos taurus | 16020 | - |
| mitochondrion | - |
Bos taurus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Cereibacter sphaeroides | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| amidopyrine + H2O2 | - |
Bos taurus | ? | - |
? | |
| benzidine + H2O2 | - |
Bos taurus | ? | - |
? | |
| diaminobenzidine + H2O2 | - |
Bos taurus | ? | - |
? | |
| melatonin + H2O2 | - |
Bos taurus | ? | - |
? | |
| additional information | numerous organic aromatic compounds, which are not oxidized by cytochrome oxidase via the oxidase mechanism (i.e. using molecular oxygen as the terminal acceptor), can undergo a low rate oxidation by cytochrome oxidase via the peroxidase mechanism. Paracetamol and isonicotinic acid hydrazide are completely resistant to peroxidation by cytochrome oxidase | Bos taurus | ? | - |
? | |
| o-dianisidine + H2O2 | - |
Bos taurus | ? | - |
? | |
| o-dianisidine + H2O2 | - |
Cereibacter sphaeroides | ? | - |
? | |
| p-phenylenediamine + H2O2 | - |
Bos taurus | ? | - |
? | |
| tetramethylbenzidine + H2O2 | - |
Bos taurus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| cytochrome c oxidase | - |
Bos taurus |
| cytochrome c oxidase | - |
Cereibacter sphaeroides |
| cytochrome oxidase | - |
Bos taurus |
| cytochrome oxidase | - |
Cereibacter sphaeroides |
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Release 2023.1 (January 2023)
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