Literature summary for 7.1.1.8 extracted from

Forquer, I.; Covian, R.; Bowman, M.K.; Trumpower, B.L.; Kramer, D.M.
Similar transition states mediate the Q-cycle and superoxide production by the cytochrome bc1 complex (2006), J. Biol. Chem., 281, 38459-38465.

Search for more literature for 7.1.1.8

Protein Variants

Protein Variants	Comment	Organism
S183A	site-directed mutagenesis, kinetic parameters compared to the wild-type enzyme	Saccharomyces cerevisiae
S183T	site-directed mutagenesis, kinetic parameters compared to the wild-type enzyme	Saccharomyces cerevisiae
Y185F	site-directed mutagenesis, kinetic parameters compared to the wild-type enzyme	Saccharomyces cerevisiae

Inhibitors

Inhibitors	Comment	Organism	Structure
Myxothiazol	-	Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
additional information	-	additional information	pre-steady-state reduction of cyt b and cyt c1, steady-state kinetics and Arrhenius activation energies of wild-type and mutant enzymes, overview	Saccharomyces cerevisiae
4.3	-	decylubiquinol	pH 8.0, mutant S183A	Saccharomyces cerevisiae
4.5	-	decylubiquinol	pH 8.0, wild-type enzyme	Saccharomyces cerevisiae
9.2	-	decylubiquinol	pH 8.0, mutant Y185F	Saccharomyces cerevisiae
12.4	-	decylubiquinol	pH 8.0, mutant S183T	Saccharomyces cerevisiae

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
mitochondrion	-	Saccharomyces cerevisiae	5739	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
ubiquinol + ferricytochrome c	Saccharomyces cerevisiae	-	ubiquinone + ferrocytochrome c	-	?

Organism

Organism	UniProt	Comment	Textmining
Saccharomyces cerevisiae	-	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
quinol + 2 ferricytochrome c = quinone + 2 ferrocytochrome c + 2 H+[side 2]	reaction mechanism, similar transition states mediate the Q-cycle and superoxide production by the cytochrome bc1 complex	Saccharomyces cerevisiae	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
decylubiquinol + ferricytochrome c	-	Saccharomyces cerevisiae	decylubiquinone + ferrocytochrome c	-	?
ubiquinol + ferricytochrome c	-	Saccharomyces cerevisiae	ubiquinone + ferrocytochrome c	-	?

Synonyms

Synonyms	Comment	Organism
cytochrome bc1 complex	-	Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
additional information	-	-	Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
8	-	assay at	Saccharomyces cerevisiae

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Release 2023.1 (January 2023)