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Literature summary for 7.1.1.8 extracted from

  • Gutierrez-Cirlos, E.B.; Merbitz-Zahradnik, T.; Trumpower, B.L.
    Inhibition of the yeast cytochrome bc1 complex by ilicicolin H, a novel inhibitor that acts at the Qn site of the bc1 complex (2004), J. Biol. Chem., 279, 8708-8714.
    View publication on PubMed
Search for more literature for 7.1.1.8

Inhibitors

Inhibitors Comment Organism Structure
Antimycin center N inhibitor, acts at the Qn site of the bc1 complex, binding mode differing from ilicicolin Saccharomyces cerevisiae
funiculosin similar to ilicicolin Saccharomyces cerevisiae
ilicicolin H center N inhibitor, the antibiotic substance acts at the Qn site of the bc1 complex, isolated from the fungus Cylindrocladium iliciola strain MFC-870, binding mode differing from antimycin, effects on kinetics Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
 additional information pre-steady-state kinetics of cytochrome b reduction Saccharomyces cerevisiae

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Saccharomyces cerevisiae 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ubiquinol-2 + 2 ferricytochrome c Saccharomyces cerevisiae enzyme complex is essentially involved in the mitochondrial respiratory electron transfer chain ubiquinone-2 + 2 ferrocytochrome c + 2 H+
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
decyl-ubiquinol + ferricytochrome c
-
 Saccharomyces cerevisiae decyl-ubiquinone + ferrocytochrome c
-
 r
ubiquinol-2 + 2 ferricytochrome c
-
 Saccharomyces cerevisiae ubiquinone-2 + 2 ferrocytochrome c + 2 H+
-
 r
ubiquinol-2 + 2 ferricytochrome c enzyme complex is essentially involved in the mitochondrial respiratory electron transfer chain Saccharomyces cerevisiae ubiquinone-2 + 2 ferrocytochrome c + 2 H+
-
 ?

Synonyms

Synonyms Comment Organism
cytochrome bc1 complex
-
 Saccharomyces cerevisiae
ubiquinol-cytochrome c reductase
-
 Saccharomyces cerevisiae

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
22
-
 assay at room temperature Saccharomyces cerevisiae

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
140 160 ubiquinol pH 7.0, 22°C Saccharomyces cerevisiae

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7
-
 assay at Saccharomyces cerevisiae

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000025
-
 Antimycin pH 7.0, 22°C Saccharomyces cerevisiae
0.0000025 0.00005 ilicicolin H pH 7.0, 22°C Saccharomyces cerevisiae