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Literature summary for 7.1.1.8 extracted from

  • Pember, S.O.; Fleck, L.C.; Moberg, W.K.; Walker, M.P.
    Mechanistic differences in inhibition of ubiquinol cytochrome c reductase by the proximal Qo-site inhibitors famoxadone and methoxyacrylate stilbene (2005), Arch. Biochem. Biophys., 435, 280-290.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
Antimycin
-
Bos taurus
famoxadone reversible, tight-binding, non-competitive inhibitor, proximal Qo-site inhibitor, binding and inhibition mechanism, overview Bos taurus
methoxyacrylate stilbene reversible, tight-binding, mixed-competitive inhibitor, proximal Qo-site inhibitor, binding and inhibition mechanism, overview Bos taurus
Stigmatellin
-
Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information steady-state kinetics Bos taurus
0.072
-
QH2 pH 7.2, 25°C Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
Bos taurus 16020
-
mitochondrion
-
Bos taurus 5739
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ubiquinol-2 + 2 ferricytochrome c Bos taurus
-
ubiquinone-2 + 2 ferrocytochrome c + 2 H+
-
?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity from heart mitochondria Bos taurus

Renatured (Commentary)

Renatured (Comment) Organism
reconstitution of the solubilized membrane-protein complex in phospholipid vesicles Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
decyl-ubiquinol + ferricytochrome c
-
Bos taurus decyl-ubiquinone + ferrocytochrome c
-
?
ubiquinol-2 + 2 ferricytochrome c
-
Bos taurus ubiquinone-2 + 2 ferrocytochrome c + 2 H+
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
25
-
assay at Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information inhibition mechanism and kinetics Bos taurus
0.000022
-
methoxyacrylate stilbene pH 7.2, 25°C Bos taurus
0.000195
-
famoxadone pH 7.2, 25°C Bos taurus