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Literature summary for 7.1.1.3 extracted from

  • Korshunov, S.; Imlay, K.R.; Imlay, J.A.
    The cytochrome bd oxidase of Escherichia coli prevents respiratory inhibition by endogenous and exogenous hydrogen sulfide (2016), Mol. Microbiol., 101, 62-77 .
    View publication on PubMedView publication on EuropePMC
Search for more literature for 7.1.1.3

Inhibitors

Inhibitors Comment Organism Structure
cystine
-
 Escherichia coli
Sulfide inhibition is fully reversible; low-micromolar levels of sulfide directly inhibit the proton-pumping cytochrome bo oxidase, but not cytochrome bd oxidase Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ubiquinol + O2 + H+[side 1] Escherichia coli
-
 ubiquinone + H2O + H+[side 2]
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-
Escherichia coli P0ABJ1 and P0ABI8 and P0ABJ3 and P0ABJ6 P0ABJ1 i.e. subunit cyoA, P0ABI8 i.e. subunit cyoB, P0ABJ3 i.e. subunit cyoC, P0ABJ6 i.e. subunit cyoD
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ubiquinol + O2 + H+[side 1]
-
 Escherichia coli ubiquinone + H2O + H+[side 2]
-
 ?

Synonyms

Synonyms Comment Organism
cytochrome bd oxidase
-
 Escherichia coli
cytochrome bo oxidase
-
 Escherichia coli

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.005
-
 cytochrome bo oxidase, at pH 7.0 and 25°C Escherichia coli Sulfide

General Information

General Information Comment Organism
physiological function the enzyme prevents respiratory inhibition by endogenous and exogenous hydrogen sulfide Escherichia coli
physiological function when cystine is provided and sulfide levels rise, Escherichia coli becomes strictly dependent upon cytochrome bd oxidase for continued respiration. Low-micromolar levels of sulfide inhibit the proton-pumping cytochrome bo oxidase. In the absence of the back-up cytochrome bd oxidase, growth fails. Exogenous sulfide elicits the same effect Escherichia coli