Inhibitors | Comment | Organism | Structure |
---|---|---|---|
3-azido-ubiquinone-2 | - |
Mycobacterium tuberculosis | |
6-amino-4-(4-tert-butylphenethylamino)quinazoline | - |
Mycobacterium tuberculosis | |
6-azido-4-(4-iodophenethylamino)quinazoline | the compound specifically binds to the 49000 Da and ND1 subunits with a frequency of about 4:1 | Mycobacterium tuberculosis | |
bullatacin | - |
Mycobacterium tuberculosis | |
fenpyroximate | - |
Mycobacterium tuberculosis | |
Piericidin A | - |
Mycobacterium tuberculosis | |
pyridabene | - |
Mycobacterium tuberculosis | |
rotenone | - |
Mycobacterium tuberculosis |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mycobacterium tuberculosis | - |
- |
- |
Mycobacterium tuberculosis H37RV (ATCC 25618) | - |
- |
- |
Synonyms | Comment | Organism |
---|---|---|
NDH-1 | the NuoG subunit of the type I NADH dehydrogenase | Mycobacterium tuberculosis |
type I NADH dehydrogenase | - |
Mycobacterium tuberculosis |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Mycobacterium tuberculosis |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.0000045 | - |
pH and temperature not specified in the publication | Mycobacterium tuberculosis | 6-amino-4-(4-tert-butylphenethylamino)quinazoline |
General Information | Comment | Organism |
---|---|---|
physiological function | the NuoG subunit of the type I NADH dehydrogenase, NDH-1, is important in Mycobacterium tuberculosis-mediated inhibition of host macrophage apoptosis, the NDH-1 complex is important for NOX2 neutralization in host macrophages | Mycobacterium tuberculosis |