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Literature summary for 7.1.1.2 extracted from

  • Murai, M.; Sekiguchi, K.; Nishioka, T.; Miyoshi, H.
    Characterization of the inhibitor binding site in mitochondrial NADH-ubiquinone oxidoreductase by photoaffinity labeling using a quinazoline-type inhibitor (2009), Biochemistry, 48, 688-698.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
3-azido-ubiquinone-2
-
Bos taurus
6-amino-4-(4-tert-butylphenethylamino)quinazoline
-
Bos taurus
6-azido-4-(4-iodophenethylamino)quinazoline the compound specifically binds to the 49000 Da and ND1 subunits with a frequency of about 4:1 Bos taurus
6-azido-N-[2-(4-tert-butylphenyl)ethyl]-6,7-dihydroquinazolin-4-amine
-
Bos taurus
bullatacin
-
Bos taurus
fenpyroximate
-
Bos taurus
Piericidin A
-
Bos taurus
pyridabene
-
Bos taurus
rotenone
-
Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus P17694
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + H+ + ubiquinone-1
-
Bos taurus NAD+ + ubiquinol-1
-
?

Synonyms

Synonyms Comment Organism
complex I
-
Bos taurus
mitochondrial proton-pumping NADH-ubiquinone oxidoreductase
-
Bos taurus
NADH-ubiquinone oxidoreductase
-
Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH
-
Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0000023
-
temperature not specified in the publication, in 20 mM Tris-HCl, pH 7.4 Bos taurus 6-azido-N-[2-(4-tert-butylphenyl)ethyl]-6,7-dihydroquinazolin-4-amine
0.0000045
-
pH and temperature not specified in the publication Bos taurus 6-amino-4-(4-tert-butylphenethylamino)quinazoline