Literature summary for 7.1.1.2 extracted from

Lin, S.S.; Kerscher, S.; Saleh, A.; Brandt, U.; Gross, U.; Bohne, W.
The Toxoplasma gondii type-II NADH dehydrogenase TgNDH2-I is inhibited by 1-hydroxy-2-alkyl-4(1H)quinolones (2008), Biochim. Biophys. Acta, 1777, 1455-1462.

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Application

Application	Comment	Organism
medicine	cellular levels of reactive oxygen species are significantly increased in cells of patients with nDNA-inherited isolated complex I deficiency. This increase is associated with variable decreases in the amount and intrinsic catalytic activity of complex I. Chronic treatment with a vitamin E derivative (Trolox) increases the amount of complex I and might provide an experimental basis for the use of antioxidants to treat complex I deficient patients	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
skin fibroblast	-	Homo sapiens	-

Synonyms

Synonyms	Comment	Organism
type-II NADH dehydrogenase TgNDH2-I	-	Homo sapiens

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Release 2023.1 (January 2023)