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Literature summary for 7.1.1.2 extracted from

  • Giusti, S.; Converso, D.P.; Poderoso, J.J.; Fiszer de Plazas, S.
    Hypoxia induces complex I inhibition and ultrastructural damage by increasing mitochondrial nitric oxide in developing CNS (2008), Eur. J. Neurosci., 27, 123-131.
    View publication on PubMed
Search for more literature for 7.1.1.2

Inhibitors

Inhibitors Comment Organism Structure
rotenone
-
 Gallus gallus
YLVCGERGFFYTPKA hypoxia causes prolonged inhibition of maximal complex I activity and ultrastructural phenotypes associated with swelling, namely, fading of cristae, intracristal dilations and membrane disruption. Administration of the selective neuronal nitric oxide synthase inhibitor 7-nitroindazole 20 min before hypoxia prevents complex I inhibition in a dose-dependent manner and most ultrastructural damage Gallus gallus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Gallus gallus 5739
-

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
 Gallus gallus
-
optic lobe
-
 Gallus gallus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + benzoquinone + H+
-
 Gallus gallus NAD+ + benzoquinol
-
 ?

Synonyms

Synonyms Comment Organism
complex I
-
 Gallus gallus
NADH: ubiquinone oxidoreductase
-
 Gallus gallus