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Literature summary for 7.1.1.2 extracted from

  • Sgobbo, P.; Pacelli, C.; Grattagliano, I.; Villani, G.; Cocco, T.
    Carvedilol inhibits mitochondrial complex I and induces resistance to H2O2 -mediated oxidative insult in H9C2 myocardial cells (2007), Biochim. Biophys. Acta, 1767, 222-232.
    View publication on PubMed

Application

Application Comment Organism
drug development carvedilol exerts its protective antioxidant action both by a direct antioxidant effect and by a preconditioning-like mechanism, via inhibition of mitochondrial complex I Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
carvedilol decreases mitochondrial complex I activity, which is associated with an increase in mitochondrial H2O2 production, total glutathione and protein thiols content Rattus norvegicus
rotenone decreases complex I activity by 25%, 27% and 48% in the presence of 0.005, 0.01 and 0.02 mM carvedilol, respectively Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Rattus norvegicus 5739
-

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
embryo
-
Rattus norvegicus
-
H9c2 cell
-
Rattus norvegicus
-
heart
-
Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + decylubiquinone + H+
-
Rattus norvegicus NAD+ + decylubiquinol
-
?

Synonyms

Synonyms Comment Organism
complex I
-
Rattus norvegicus
NADH-CoQ oxidoreductase
-
Rattus norvegicus