Application | Comment | Organism |
---|---|---|
drug development | carvedilol exerts its protective antioxidant action both by a direct antioxidant effect and by a preconditioning-like mechanism, via inhibition of mitochondrial complex I | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
carvedilol | decreases mitochondrial complex I activity, which is associated with an increase in mitochondrial H2O2 production, total glutathione and protein thiols content | Rattus norvegicus | |
rotenone | decreases complex I activity by 25%, 27% and 48% in the presence of 0.005, 0.01 and 0.02 mM carvedilol, respectively | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
embryo | - |
Rattus norvegicus | - |
H9c2 cell | - |
Rattus norvegicus | - |
heart | - |
Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADH + decylubiquinone + H+ | - |
Rattus norvegicus | NAD+ + decylubiquinol | - |
? |
Synonyms | Comment | Organism |
---|---|---|
complex I | - |
Rattus norvegicus |
NADH-CoQ oxidoreductase | - |
Rattus norvegicus |