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Literature summary for 7.1.1.2 extracted from

  • Tarasiuk, J.; Mazerski, J.; Tkaczyk-Gobis, K.; Borowski, E.
    Molecular basis of the low activity of antitumor anthracenediones, mitoxantrone and ametantrone, in oxygen radical generation catalyzed by NADH dehydrogenase. Enzymatic and molecular modelling studies (2005), Eur. J. Med. Chem., 40, 321-328.
    View publication on PubMed
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KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.036
-
 ferricytochrome c in the presence of 0.1 mM daunorubicin Mus musculus
0.0571
-
 ferricytochrome c in the presence of 0.1 mM mitoxantrone Mus musculus
0.0684
-
 ferricytochrome c in the presence of 0.1 mM ametantrone Mus musculus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 ferricytochrome c + NADH
-
 Mus musculus 2 ferrocytochrome c + NAD+ + H+
-
 ?
NADH + ferricytochrome c
-
 Mus musculus NAD+ + H+ + ferrocytochrome c
-
 ?

Synonyms

Synonyms Comment Organism
mitochondrial NADH dehydrogenase
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Mus musculus