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Literature summary for 7.1.1.2 extracted from

  • Fujita, D.; Murai, M.; Nishioka, T.; Miyoshi, H.
    Light control of mitochondrial complex I activity by a photoresponsive inhibitor (2006), Biochemistry, 45, 6581-6586.
    View publication on PubMed
Search for more literature for 7.1.1.2

Inhibitors

Inhibitors Comment Organism Structure
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diylbis(5-[4-[(E)-(4-butylphenyl)diazenyl]phenoxy]pentan-1-ol) 48 nM, 70% inhibition Bos taurus
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diylbis(5-[4-[(Z)-(4-butylphenyl)diazenyl]phenoxy]pentan-1-ol) 48 nM, 70% inhibition Bos taurus
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diylbis[6-(2-butylphenoxy)hexan-1-ol] IC50: 1000 nM Bos taurus
(1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diylbis[6-(4-butylphenoxy)hexan-1-ol] IC50: 0.83 nM Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + ubiquinone
-
 Bos taurus NAD+ + ubiquinol
-
 ?

Synonyms

Synonyms Comment Organism
complex I
-
 Bos taurus
NADH-ubiquinone oxidoreductase
-
 Bos taurus

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Bos taurus

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00000083
-
 IC50: 0.83 nM Bos taurus (1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diylbis[6-(4-butylphenoxy)hexan-1-ol]
0.001
-
 IC50: 1000 nM Bos taurus (1R,1'R)-1,1'-(2R,2'R,5R,5'R)-octahydro-2,2'-bifuran-5,5'-diylbis[6-(2-butylphenoxy)hexan-1-ol]