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Literature summary for 7.1.1.2 extracted from

  • Lambert, A.J.; Brand, M.D.
    Superoxide production by NADH:ubiquinone oxidoreductase (complex I) depends on the pH gradient across the mitochondrial inner membrane (2004), Biochem. J., 382, 511-517.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Rattus norvegicus 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus superoxide production from complex I is large under conditions of reverse electron transport. Production of superoxide by complex I during reverse electron transport is at least 3fold more sensitive to the pH gradient than to the membrane potential ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
skeletal muscle
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information superoxide production from complex I is large under conditions of reverse electron transport. Production of superoxide by complex I during reverse electron transport is at least 3fold more sensitive to the pH gradient than to the membrane potential Rattus norvegicus ?
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 ?

Synonyms

Synonyms Comment Organism
complex I
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 Rattus norvegicus
NADH:ubiquinone oxidoreductase
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 Rattus norvegicus

pH Range

pH Minimum pH Maximum Comment Organism
additional information
-
 production of superoxide by complex I during reverse electron transport is at least 3fold more sensitive to the pH gradient than to the membrane potential Rattus norvegicus