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Literature summary for 7.1.1.2 extracted from
- The mitochondrial electron transport and oxidative phosphorylation system (1985), Annu. Rev. Biochem., 54, 1015-1069.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ferricyanide | inhibits the interaction of the oxidized enzyme with NADH | Bos taurus |  |
| NADH | inhibits the interaction of the reduced enzyme with ferricyanide | Bos taurus | |
| rotenone | - |
Bos taurus | |
| rotenone | - |
Paracoccus denitrificans | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.014 | - |
NADH | - |
Bos taurus | |
| 0.04 | - |
ubiquinone-1 | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Paracoccus denitrificans | 16020 | - |
| mitochondrion | - |
Bos taurus | 5739 | - |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Iron | - |
Paracoccus denitrificans | |
| Iron | 5 binuclear and three tetranuclear iron-sulfur clusters | Bos taurus | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADH + ubiquinone | Paracoccus denitrificans | - |
? | - |
? | |
| NADH + ubiquinone | Bos taurus | vectorial electron translocation is coupled to electron transfer | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | - |
- |
- |
| Paracoccus denitrificans | - |
- |
- |
Posttranslational Modification
| Posttranslational Modification | Comment | Organism |
|---|---|---|
| lipoprotein | the enzyme complex contains phospholipids | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Bos taurus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| NADH + ubiquinone | - |
Paracoccus denitrificans | NAD+ + ubiquinol | - |
? | |
| NADH + ubiquinone | - |
Bos taurus | NAD+ + ubiquinol | - |
? | |
| NADH + ubiquinone | - |
Paracoccus denitrificans | ? | - |
? | |
| NADH + ubiquinone | vectorial electron translocation is coupled to electron transfer | Bos taurus | ? | - |
? | |
| NADH + ubiquinone-1 | - |
Bos taurus | NAD+ + ubiquinol-1 | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| More | - |
Paracoccus denitrificans |
| More | enzyme complex contains approximately 25 unlike polypeptides in three distinct fragments: 1. HP: contains the bulk of phospholipids of the complex I. 2. IP: contains polypeptides of 75000 Da, 49000 Da, 30000 Da, 18000 Da, 15000 Da and 13000 Da, 3. FP: contains polypeptides of 9000 Da, 24000 Da, and 51000 Da. FP and IP are surrounded by HP polypeptides | Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FMN | - |
Paracoccus denitrificans | |
| FMN | enzyme contains FMN | Bos taurus | |
| NADH | - |
Paracoccus denitrificans | |
| NADH | - |
Bos taurus | |
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