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Literature summary for 7.1.1.2 extracted from

  • Degli Esposti, M.; Ghelli, A.; Ratta, M.; Cortes, D.; Estornell, E.
    Natural substances (acetogenins) from the family Annonaceae are powerful inhibitors of mitochondrial NADH dehydrogenase (complex I) (1994), Biochem. J., 301, 161-167.
No PubMed abstract available
Search for more literature for 7.1.1.2

Inhibitors

Inhibitors Comment Organism Structure
molvizarin
-
 Bos taurus
otivarin
-
 Bos taurus
piercidin
-
 Bos taurus
rolliniastatin-1
-
 Bos taurus
rolliniastatin-2
-
 Bos taurus
rotenone
-
 Bos taurus
squamocin
-
 Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + ubiquinone
-
 Bos taurus NAD+ + ubiquinol
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Bos taurus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0003
-
 rolliniastatin-1
-
 Bos taurus
0.0004
-
 squamocin
-
 Bos taurus
0.0006
-
 rolliniastatin-2
-
 Bos taurus
0.0008
-
 otivarin
-
 Bos taurus
0.001
-
 molvizarin
-
 Bos taurus
0.001
-
 piercidin
-
 Bos taurus
0.004
-
 rotenone
-
 Bos taurus