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Literature summary for 7.1.1.2 extracted from

  • Grivennikova, V.G.; Kapustin, A.N.; Vinogradov, A.D.
    Catalytic activity of NADH-ubiquinone oxidoreductase (complex I) in intact mitochondria: evidence for the slow active/inactive transition (2001), J. Biol. Chem., 276, 9038-9044.
    View publication on PubMed
Search for more literature for 7.1.1.2

Activating Compound

Activating Compound Comment Organism Structure
additional information brief exposure of the thermally deactivated mitochondria with malate/glutamate, NAD+ and cytochrome c induced reactivation of the inactivated enzyme, exposure to 37°C induces deactivation of complex I Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
Mg2+ inhibition of the enzyme in its inactive form, in its active form the enzyme complex is not sensitive Bos taurus
NEM inhibition of the enzyme in its inactive form, in its active form the enzyme complex is not sensitive Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
 Bos taurus 5739
-

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
heart
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
NADH + ubiquinone
-
 Bos taurus NAD+ + ubiquinol
-
 ?

Cofactor

Cofactor Comment Organism Structure
NADH
-
 Bos taurus