Inhibitors | Comment | Organism | Structure |
---|---|---|---|
rotenone | mitochondria contain two different NADH:ubiquinone reductases. One enzyme oxidizes endogenous NADH, couples electron transfer to proton translocation and is inhibited by rotenone, the other enzyme oxidizes exogenous NADH without proton tranlocation and is insensitive to rotenone. The activity of the rotenone-insensitive enzyme highly exceeds the activity of the rotenone-sensitive enzyme | Neurospora crassa |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | the mitochondrial multienzyme-complex is of dual origin. 6 of the at least 22 subunits with MW of 70000 Da, 48000 Da, 37000 Da, 25000 Da, 22000 Da and 18000 Da are synthesized in mitochondria. 11 subunits are synthesized in the cytoplasm | Neurospora crassa | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Neurospora crassa | - |
rotenone-sensitive enzyme | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
NADH + ubiquinone | - |
Neurospora crassa | NAD+ + ubiquinol | - |
? |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
NADH | - |
Neurospora crassa |