Literature summary for 7.1.1.1 extracted from

Grimley, R.L.; Quirk, P.G.; Bizouarn, T.; Thomas, C.M.; Jackson, J.B.
Role of methionine-239, an amino acid residue in the mobile-loop region of the NADH-binding domain (domain I) of proton-translocating transhydrogenase (1997), Biochemistry, 36, 14762-14770.

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Protein Variants

Protein Variants	Comment	Organism
M239F	the Km for APAD+ during reverse transhydrogenation is 6fold greater compared to the wild type. Cyclic transhydrogenation (in membranes and the recombinant system) is substantially more inhibited (84%) than either forward or reverse transhydrogenation	Rhodospirillum rubrum
M293I	the Km for APAD+ during reverse transhydrogenation is 5fold greater compared to the wild type. Cyclic transhydrogenation (in membranes and the recombinant system) is substantially more inhibited (70%) than either forward or reverse transhydrogenation	Rhodospirillum rubrum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
membrane	-	Rhodospirillum rubrum	16020	-

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
NADPH + NAD+ + H+[side 1]	Rhodospirillum rubrum	-	NADP+ + NADH + H+[side 2]	-	?

Organism

Organism	UniProt	Comment	Textmining
Rhodospirillum rubrum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
NADPH + NAD+ + H+[side 1]	-	Rhodospirillum rubrum	NADP+ + NADH + H+[side 2]	-	?
NADPH + oxidized 3-acetylpyridin-adenine dinucleotide + H+[side 1]	-	Rhodospirillum rubrum	NADP+ + reduced 3-acetylpyridin-adenine dinucleotide + H+[side 2]	-	?

Synonyms

Synonyms	Comment	Organism
proton-translocating transhydrogenase	-	Rhodospirillum rubrum

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Release 2023.1 (January 2023)