Literature summary for 7.1.1.1 extracted from

Bragg, P.D.; Hou, C.
The presence of an aqueous cavity in the proton-pumping pathway of the pyridine nucleotide transhydrogenase of Escherichia coli is suggested by the reaction of the enzyme with sulfhydryl inhibitors (2000), Arch. Biochem. Biophys., 380, 141-150.

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Protein Variants

Protein Variants	Comment	Organism
D213K	mutation in domain II	Escherichia coli
D213R	mutation in domain II	Escherichia coli
H91K	mutation in domain II, leads to occlusion of NADP(H) at the NADP(H)-binding site of domain III	Escherichia coli
H91R	mutation in domain II, leads to occlusion of NADP(H) at the NADP(H)-binding site of domain III	Escherichia coli
N222K	mutation in domain II, leads to occlusion of NADP(H) at the NADP(H)-binding site of domain III	Escherichia coli
N222R	mutation in domain II, leads to occlusion of NADP(H) at the NADP(H)-binding site of domain III	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-

Cofactor

Cofactor	Comment	Organism	Structure
NAD+	-	Escherichia coli
NADH	-	Escherichia coli
NADP+	-	Escherichia coli
NADPH	-	Escherichia coli

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Release 2023.1 (January 2023)