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Literature summary for 6.5.1.3 extracted from

  • Durrant, J.D.; Hall, L.; Swift, R.V.; Landon, M.; Schnaufer, A.; Amaro, R.E.
    Novel naphthalene-based inhibitors of Trypanosoma brucei RNA editing ligase 1 (2010), PLoS Negl. Trop. Dis., 4, e803.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.5.1.3

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Sf9 insect cells Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
2-naphthoic acid
-
 Trypanosoma brucei
2-nitronaphthalene
-
 Trypanosoma brucei
4,5-dihydroxynaphthalene-2,7-disulfonate
-
 Trypanosoma brucei
4-hydroxy-3-[(E)-(5-hydroxy-7-sulfonaphthalen-2-yl)diazenyl]-7-[(1-phenylethenyl)amino]naphthalene-2-sulfonic acid
-
 Trypanosoma brucei
6-hydroxy-5-[(E)-[3-[(E)-(2-hydroxynaphthalen-1-yl)diazenyl]-5-sulfophenyl]diazenyl]naphthalene-2-sulfonic acid
-
 Trypanosoma brucei
7,7'-iminobis(4-hydroxynaphthalene-2-sulfonic acid)
-
 Trypanosoma brucei
7-amino-4-hydroxy-3-[(E)-(5-hydroxy-7-sulfonaphthalen-2-yl)diazenyl]naphthalene-2-sulfonic acid
-
 Trypanosoma brucei
naphthalene-2-sulfonic acid
-
 Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei P86927
-
-

Purification (Commentary)

Purification (Comment) Organism
purified via a C-terminal tandem affinity purification tag Trypanosoma brucei

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (ribonucleotide)n + (ribonucleotide)m
-
 Trypanosoma brucei AMP + diphosphate + (ribonucleotide)n+m
-
 ?

Synonyms

Synonyms Comment Organism
REL1
-
 Trypanosoma brucei
RNA editing ligase 1
-
 Trypanosoma brucei

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00153
-
 pH and temperature not specified in the publication Trypanosoma brucei 7-amino-4-hydroxy-3-[(E)-(5-hydroxy-7-sulfonaphthalen-2-yl)diazenyl]naphthalene-2-sulfonic acid
0.00159
-
 pH and temperature not specified in the publication Trypanosoma brucei 6-hydroxy-5-[(E)-[3-[(E)-(2-hydroxynaphthalen-1-yl)diazenyl]-5-sulfophenyl]diazenyl]naphthalene-2-sulfonic acid
0.00216
-
 pH and temperature not specified in the publication Trypanosoma brucei 4-hydroxy-3-[(E)-(5-hydroxy-7-sulfonaphthalen-2-yl)diazenyl]-7-[(1-phenylethenyl)amino]naphthalene-2-sulfonic acid
0.00836
-
 pH and temperature not specified in the publication Trypanosoma brucei 7,7'-iminobis(4-hydroxynaphthalene-2-sulfonic acid)

General Information

General Information Comment Organism
physiological function RNA editing ligase 1 is a key component of the trypanosomatid editosome Trypanosoma brucei