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Literature summary for 6.5.1.3 extracted from

  • Amaro, R.E.; Schnaufer, A.; Interthal, H.; Hol, W.; Stuart, K.D.; McCammon, J.A.
    Discovery of drug-like inhibitors of an essential RNA-editing ligase in Trypanosoma brucei (2008), Proc. Natl. Acad. Sci. USA, 105, 17278-17283.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 6.5.1.3

Crystallization (Commentary)

Crystallization (Comment) Organism
virtual screen of REL1 crystal structure for inhibitors Trypanosoma brucei

Inhibitors

Inhibitors Comment Organism Structure
1-amino-4-(3-(aminosulfonyl)anilino)-9,10-dioxo-9,10-dihydro-2-anthracenesulfonic acid 68.5% residual activity at 0.01 mM, presence of Triton X-100. Molecular dynamics simulations Trypanosoma brucei
3-((4-(ethylamino)phenyl)diazenyl)-4,5-dihydroxy-2,7-naphthalenedisulfonic acid 4.1% residual activity at 0.01 mM, presence of Triton X-100. Molecular dynamics simulations Trypanosoma brucei
3-((5-chloro-2-hydroxyphenyl)diazenyl)-4,5-dihydroxy-2,7-naphthalenedisulfonic acid 8.6% residual activity at 0.01 mM, presence of Triton X-100. Molecular dynamics simulations Trypanosoma brucei
4,5-dihydroxy-3-(1-naphthyldiazenyl)-2,7-naphthalenedisulfonic acid 43.1% residual activity at 0.01 mM, presence of Triton X-100. Molecular dynamics simulations Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei P86927
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-

Synonyms

Synonyms Comment Organism
REL1
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 Trypanosoma brucei
RNA-editing ligase 1
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 Trypanosoma brucei