Literature summary for 6.5.1.3 extracted from

Nandakumar, J.; Shuman, S.; Lima, C.D.
RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward (2006), Cell, 127, 71-84.

Crystallization (Commentary)

Crystallization (Comment)	Organism
hanging-drop vapor diffusion. Crystal structures of: 1. Covalent Rnl2-AMP intermediate, 2. Rnl2 bound to an adenylylated nicked duplex, captured immediately following reaction step 2, 3. Rnl2 at an adenylylated nick in a state poised for step 3. These structures illuminate the stereochemistry of nucleotidyl transfer and reveal how remodeling of active-site contacts and conformational changes propel the ligation reaction forward	Tequatrovirus T4

Crystallization (Comment)

Organism

hanging-drop vapor diffusion. Crystal structures of: 1. Covalent Rnl2-AMP intermediate, 2. Rnl2 bound to an adenylylated nicked duplex, captured immediately following reaction step 2, 3. Rnl2 at an adenylylated nick in a state poised for step 3. These structures illuminate the stereochemistry of nucleotidyl transfer and reveal how remodeling of active-site contacts and conformational changes propel the ligation reaction forward

Tequatrovirus T4

Organism

Organism	UniProt	Comment	Textmining
Tequatrovirus T4	P32277	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Tequatrovirus T4

Source Tissue

Source Tissue	Comment	Organism	Textmining

Synonyms

Synonyms	Comment	Organism
RNA ligase 2	-	Tequatrovirus T4
Rnl2	-	Tequatrovirus T4

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)