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Literature summary for 6.5.1.2 extracted from

  • Murphy-Benenato, K.; Wang, H.; McGuire, H.M.; Davis, H.E.; Gao, N.; Prince, D.B.; Jahic, H.; Stokes, S.S.; Boriack-Sjodin, P.A.
    Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations (2014), Bioorg. Med. Chem. Lett., 24, 360-366.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
-
Enterococcus faecalis
(2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
-
Haemophilus influenzae
(2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
-
Staphylococcus aureus
(2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
-
Streptococcus pneumoniae
2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
-
Enterococcus faecalis
2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
-
Haemophilus influenzae
2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
-
Staphylococcus aureus
2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
-
Streptococcus pneumoniae
2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
-
Enterococcus faecalis
2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
-
Haemophilus influenzae
2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
-
Staphylococcus aureus
2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
-
Streptococcus pneumoniae
2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
-
Enterococcus faecalis
2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
-
Haemophilus influenzae
2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
-
Staphylococcus aureus
2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
-
Streptococcus pneumoniae
4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
Enterococcus faecalis
4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
Haemophilus influenzae
4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
Staphylococcus aureus
4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
Streptococcus pneumoniae
4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
Enterococcus faecalis
4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
Haemophilus influenzae
4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
Staphylococcus aureus
4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
Streptococcus pneumoniae
4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
-
Enterococcus faecalis
4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
-
Haemophilus influenzae
4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
-
Staphylococcus aureus
4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
-
Streptococcus pneumoniae
4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
-
Enterococcus faecalis
4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
-
Haemophilus influenzae
4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
-
Staphylococcus aureus
4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
-
Streptococcus pneumoniae
4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
Enterococcus faecalis
4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
Haemophilus influenzae
4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
Staphylococcus aureus
4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
-
Streptococcus pneumoniae
4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
-
Enterococcus faecalis
4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
-
Haemophilus influenzae
4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
-
Staphylococcus aureus
4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
-
Streptococcus pneumoniae
4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
Enterococcus faecalis
4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
Haemophilus influenzae
4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
Staphylococcus aureus
4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
-
Streptococcus pneumoniae
4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
-
Enterococcus faecalis
4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
-
Haemophilus influenzae
4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
-
Staphylococcus aureus
4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
-
Streptococcus pneumoniae
4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
-
Enterococcus faecalis
4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
-
Haemophilus influenzae
4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
-
Staphylococcus aureus
4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
-
Streptococcus pneumoniae
4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
-
Enterococcus faecalis
4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
-
Haemophilus influenzae
4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
-
Staphylococcus aureus
4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
-
Streptococcus pneumoniae
4-aminothieno[3,2-c]pyridine-7-carboxamide
-
Enterococcus faecalis
4-aminothieno[3,2-c]pyridine-7-carboxamide
-
Haemophilus influenzae
4-aminothieno[3,2-c]pyridine-7-carboxamide
-
Staphylococcus aureus
4-aminothieno[3,2-c]pyridine-7-carboxamide
-
Streptococcus pneumoniae
ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
-
Enterococcus faecalis
ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
-
Haemophilus influenzae
ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
-
Staphylococcus aureus
ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
-
Streptococcus pneumoniae

Organism

Organism UniProt Comment Textmining
Enterococcus faecalis
-
-
-
Haemophilus influenzae
-
-
-
Staphylococcus aureus
-
-
-
Streptococcus pneumoniae
-
-
-

Synonyms

Synonyms Comment Organism
LigA
-
Staphylococcus aureus
LigA
-
Haemophilus influenzae
LigA
-
Enterococcus faecalis
LigA
-
Streptococcus pneumoniae

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.00021
-
pH and temperature not specified in the publication Streptococcus pneumoniae (2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
0.00043
-
pH and temperature not specified in the publication Staphylococcus aureus (2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
0.00051
-
pH and temperature not specified in the publication Haemophilus influenzae (2R,3R,4S,5R)-2-[6-amino-2-(cyclopentyloxy)-9H-purin-9-yl]-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
0.003
-
pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
0.0071
-
pH and temperature not specified in the publication Staphylococcus aureus 4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
0.0081
-
pH and temperature not specified in the publication Enterococcus faecalis 4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
0.0089
-
pH and temperature not specified in the publication Staphylococcus aureus ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
0.0094
-
pH and temperature not specified in the publication Streptococcus pneumoniae 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
0.0094
-
pH and temperature not specified in the publication Streptococcus pneumoniae ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
0.015
-
pH and temperature not specified in the publication Staphylococcus aureus 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
0.021
-
pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
0.025
-
pH and temperature not specified in the publication Streptococcus pneumoniae 4-aminothieno[3,2-c]pyridine-7-carboxamide
0.029
-
pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
0.034
-
pH and temperature not specified in the publication Enterococcus faecalis 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
0.036
-
pH and temperature not specified in the publication Staphylococcus aureus 4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
0.036
-
pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
0.039
-
pH and temperature not specified in the publication Staphylococcus aureus 4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
0.048
-
pH and temperature not specified in the publication Staphylococcus aureus 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
0.052
-
pH and temperature not specified in the publication Streptococcus pneumoniae 4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
0.069
-
pH and temperature not specified in the publication Staphylococcus aureus 4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
0.074
-
pH and temperature not specified in the publication Enterococcus faecalis ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
0.075
-
pH and temperature not specified in the publication Staphylococcus aureus 4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
0.077
-
pH and temperature not specified in the publication Enterococcus faecalis 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
0.1
-
pH and temperature not specified in the publication Enterococcus faecalis 4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
0.1
-
pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
0.13
-
pH and temperature not specified in the publication Enterococcus faecalis 4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
0.13
-
pH and temperature not specified in the publication Enterococcus faecalis 2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
0.14
-
pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
0.14
-
value above, pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
0.15
-
pH and temperature not specified in the publication Streptococcus pneumoniae 2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
0.15
-
pH and temperature not specified in the publication Staphylococcus aureus 2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
0.16
-
pH and temperature not specified in the publication Haemophilus influenzae 4-amino-2-bromothieno[3,2-c]pyridine-7-carboxamide
0.16
-
pH and temperature not specified in the publication Haemophilus influenzae 2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
0.16
-
pH and temperature not specified in the publication Enterococcus faecalis 2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
0.18
-
pH and temperature not specified in the publication Staphylococcus aureus 2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
0.2
-
pH and temperature not specified in the publication Streptococcus pneumoniae 4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
0.2
-
pH and temperature not specified in the publication Haemophilus influenzae 2-bromo-4-(propylamino)thieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Haemophilus influenzae 4-amino-2-bromo-3-methylthieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Staphylococcus aureus 4-aminothieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Haemophilus influenzae 4-aminothieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Enterococcus faecalis 4-aminothieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Staphylococcus aureus 4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Haemophilus influenzae 4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Enterococcus faecalis 4-amino-2-methylthieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Haemophilus influenzae 4-aminothieno[3,2-c]pyridine-2,7-dicarboxamide
0.2
-
value above, pH and temperature not specified in the publication Haemophilus influenzae ethyl 4-amino-7-carbamoylthieno[3,2-c]pyridine-2-carboxylate
0.2
-
value above, pH and temperature not specified in the publication Haemophilus influenzae 4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
0.2
-
value above, pH and temperature not specified in the publication Enterococcus faecalis 4-amino-N2-ethylthieno[3,2-c]pyridine-2,7-dicarboxamide
0.2
-
value above, pH and temperature not specified in the publication Haemophilus influenzae 4-amino-2-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Haemophilus influenzae 4-amino-3-bromothieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Staphylococcus aureus 4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Haemophilus influenzae 4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Enterococcus faecalis 4-amino-3-methylthieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Haemophilus influenzae 4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
0.2
-
value above, pH and temperature not specified in the publication Enterococcus faecalis 4-aminothieno[3,2-c]pyridine-3,7-dicarboxamide
0.2
-
value above, pH and temperature not specified in the publication Staphylococcus aureus 4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Haemophilus influenzae 4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Enterococcus faecalis 4-amino-3-(1H-pyrazol-5-yl)thieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Streptococcus pneumoniae 2-bromo-4-(phenylamino)thieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Staphylococcus aureus 2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Haemophilus influenzae 2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Enterococcus faecalis 2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide
0.2
-
value above, pH and temperature not specified in the publication Streptococcus pneumoniae 2-bromo-4-[(2-hydroxyethyl)amino]thieno[3,2-c]pyridine-7-carboxamide