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BRENDA support

Literature summary for 6.5.1.1 extracted from

  • Simsek, D.; Brunet, E.; Wong, S.Y.; Katyal, S.; Gao, Y.; McKinnon, P.J.; Lou, J.; Zhang, L.; Li, J.; Rebar, E.J.; Gregory, P.D.; Holmes, M.C.; Jasin, M.
    DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation (2011), PLoS Genet., 7, e1002080.
    View publication on PubMedView publication on EuropePMC

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Mus musculus 5739
-

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m
-
Mus musculus AMP + diphosphate + (deoxyribonucleotide)m+n
-
?

Synonyms

Synonyms Comment Organism
DNA ligase III
-
Mus musculus
Lig3
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Mus musculus

General Information

General Information Comment Organism
malfunction deletion of Lig3 results in cellular lethality. Translocations are reduced in frequency in the absence of Lig3. alternative nonhomologous end-joining is impaired with Lig3 loss. Deletion of the zinc finger domain of Lig3, but not the XRCC1-interacting BRCT domain, affects translocation frequency and outcome Mus musculus
physiological function Lig3 promotes alternative nonhomologous end-joining during chromosomal translocation formation. Lig3 is essential for mitochondrial DNA metabolism Mus musculus