Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + (deoxyribonucleotide)n + (deoxyribonucleotide)m | - |
Mus musculus | AMP + diphosphate + (deoxyribonucleotide)m+n | - |
? |
Synonyms | Comment | Organism |
---|---|---|
DNA ligase III | - |
Mus musculus |
Lig3 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | deletion of Lig3 results in cellular lethality. Translocations are reduced in frequency in the absence of Lig3. alternative nonhomologous end-joining is impaired with Lig3 loss. Deletion of the zinc finger domain of Lig3, but not the XRCC1-interacting BRCT domain, affects translocation frequency and outcome | Mus musculus |
physiological function | Lig3 promotes alternative nonhomologous end-joining during chromosomal translocation formation. Lig3 is essential for mitochondrial DNA metabolism | Mus musculus |